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T2803

Sigma-Aldrich

7-Ethoxy-4-(trifluoromethyl)coumarin

≥98% (TLC), powder

Sinonimo/i:

Ethyl 4-(trifluoromethyl)umbelliferyl ether

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About This Item

Formula empirica (notazione di Hill):
C12H9F3O3
Numero CAS:
115453-82-2
Peso molecolare:
258.19
Beilstein:
8555209
Numero MDL:
MFCD00467588
Codice UNSPSC:
12352204
ID PubChem:
24900082
NACRES:
NA.32

product name

7-Ethoxy-4-(trifluoromethyl)coumarin, ≥98% (TLC)

Saggio

≥98% (TLC)

Forma fisica

powder

Solubilità

chloroform: 100 mg/mL, clear, colorless (Soluble in chloroform, methanol, and DMSO.)

Fluorescenza

λex 333 nm; λem 415 nm in methanol

Temperatura di conservazione

−20°C

Stringa SMILE

CCOc1ccc2c(OC(=O)C=C2C(F)(F)F)c1

InChI

1S/C12H9F3O3/c1-2-17-7-3-4-8-9(12(13,14)15)6-11(16)18-10(8)5-7/h3-6H,2H2,1H3
OLHOIERZAZMHGK-UHFFFAOYSA-N

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Caratteristiche e vantaggi

7-Ethoxy-4-(trifluoromethyl)coumarin is a fluorogenic substrate for cytochrome P-450 catalyzed O-de-ethylation.

Confezionamento

Bottomless glass bottle. Contents are inside inserted fused cone.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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J G DeLuca et al.
Biochemical pharmacology, 37(9), 1731-1739 (1988-05-01)
The microsomal O-deethylation of a novel coumarin analog, 7-ethoxy-4-trifluoromethylcoumarin (EFC), to a fluorescent product was characterized. Results indicate that this analog provides a rapid, convenient and highly sensitive means to assay cytochrome P-450-mediated metabolism. Like microsomal 7-ethoxycoumarin (7-EC) O-deethylation, EFC
Emily E Scott et al.
Chemical research in toxicology, 15(11), 1407-1413 (2002-11-20)
Until recently, all known structures of bacterial cytochromes P450 suggested that substrate access to the buried active site occurred via the F-G region, a surface loop distal to the heme cavity. However, the structure of P450 51 indicates a large
Chitra Sridar et al.
The Journal of pharmacology and experimental therapeutics, 301(3), 945-952 (2002-05-23)
Tamoxifen is primarily used in the treatment of breast cancer. It has been approved as a chemopreventive agent for individuals at high risk for this disease. Tamoxifen is metabolized to a number of different products by cytochrome P450 enzymes. The
Shih-Feng Lan et al.
Toxicology in vitro : an international journal published in association with BIBRA, 24(4), 1314-1323 (2010-02-23)
In this study, we have evaluated the use of ultra-sterile alginate hydrogels encapsulated with HepG2 liver cells for applications in high throughput drug screening. We have studied the cellular viability and metabolic capacity of the encapsulated cells in two different
Xilin Li et al.
Toxicological sciences : an official journal of the Society of Toxicology, 175(2), 251-265 (2020-03-12)
Metabolism plays a key role in chemical genotoxicity; however, most mammalian cells used for in vitro genotoxicity testing lack effective metabolizing enzymes. We recently developed a battery of TK6-derived cell lines that individually overexpress 1 of 8 cytochrome P450s (CYP1A1
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