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T133

Sigma-Aldrich

Inactin® hydrate

≥98% (HPLC)

Sinonimo/i:

Thiobutabarbital sodium salt hydrate

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About This Item

Formula empirica (notazione di Hill):
C10H15N2NaO2S · xH2O
Numero CAS:
947-08-0
Peso molecolare:
250.29 (anhydrous basis)
Numero CE:
213-425-3
Numero MDL:
MFCD00214068
Codice UNSPSC:
12352200
ID PubChem:
24899957
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥98% (HPLC)

Forma fisica

powder

Controllo stupefacenti

USDEA Schedule IIIN; regulated under CDSA - not available from Sigma-Aldrich Canada

Colore

light yellow

Solubilità

H2O: soluble (storage of solutions for more than 8 hours at 4°C is not recommended.)

Stringa SMILE

[Na+].CCC(C)C1(CC)C([O-])=NC(=S)NC1=O

InChI

1S/C10H16N2O2S.Na/c1-4-6(3)10(5-2)7(13)11-9(15)12-8(10)14;/h6H,4-5H2,1-3H3,(H2,11,12,13,14,15);/q;+1/p-1
SLZHLQUFNFXTHB-UHFFFAOYSA-M

Applicazioni

Inactin® hydrate has been used to anesthetize rats to study stress-induced hypersensitivity and mice to study Cisplatin-induced neuropathy. It has also been used to anesthetize rats to measure the glomerular filtration rate (GFR).

Azioni biochim/fisiol

Inactin® is a long-lasting rodent anesthetic with minimal effects on cardiovascular tone and renal output. It exhibits sedative and hypnotic properties.

Note legali

Inactin is a registered trademark of Merck KGaA, Darmstadt, Germany

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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Eman Y Gohar et al.
Journal of the American Heart Association, 9(10), e015110-e015110 (2020-05-12)
Background The novel estrogen receptor, G-protein-coupled estrogen receptor (GPER), is responsible for rapid estrogen signaling. GPER activation elicits cardiovascular and nephroprotective effects against salt-induced complications, yet there is no direct evidence for GPER control of renal Na+ handling. We hypothesized
J Buelke-Sam et al.
Laboratory animal science, 28(2), 157-162 (1978-04-01)
Rats were anesthetized with pentobarbital, pentobarbital and atropine, inactin [5-ethyl-5-(1'-methyl-propyl)-2-thiobarbiturate], ether and inactin, or urethane. Cardiovascular and arterial acid-base parameters were monitored over a 3-hour period of anesthesia. Heart rate, arterial pressures, and pH progressively decreased with duration of pentobarbital
Haiyun Qi et al.
Magnetic resonance in medicine, 80(5), 2073-2080 (2018-03-10)
Anesthesia is necessary for most animal studies requiring invasive procedures. It is well documented that various types of anesthesia modulate a wide variety of important metabolic and functional processes in the body, and as such, represent a potential limitation in
Maki Niihori et al.
American journal of respiratory cell and molecular biology, 62(2), 231-242 (2019-08-29)
NFU1 is a mitochondrial protein that is involved in the biosynthesis of iron-sulfur clusters, and its genetic modification is associated with disorders of mitochondrial energy metabolism. Patients with autosomal-recessive inheritance of the NFU1 mutation G208C have reduced activity of the
Min-Suk Yoon et al.
BMC neuroscience, 10, 77-77 (2009-07-16)
Cisplatin mediates its antineoplastic activity by formation of distinct DNA intrastrand cross links. The clinical efficacy and desirable dose escalations of cisplatin are restricted by the accumulation of DNA lesions in dorsal root ganglion (DRG) cells leading to sensory polyneuropathy
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