SRP6297
Cathepsin S human
recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)
Sinonimo/i:
CTSS
Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
About This Item
Codice UNSPSC:
12352200
NACRES:
NA.32
Prodotti consigliati
Origine biologica
human
Ricombinante
expressed in HEK 293 cells
Saggio
≥95% (SDS-PAGE)
Forma fisica
liquid
PM
~37 kDa
Confezionamento
pkg of 10 μg
pkg of 50 μg
Concentrazione
0.2 μM
N° accesso UniProt
Condizioni di spedizione
dry ice
Temperatura di conservazione
−70°C
Informazioni sul gene
human ... CTSS(1520)
Descrizione generale
Cathepsin S (CTSS) is a lysosomal cysteine endopeptidase of the papain family or C1 family. It is produced as an inactive preproenzyme which is then converted into the active form in lysosomes and late endosomes.
Azioni biochim/fisiol
Cathepsin S (CTSS) is a key participant in MHC (major histocompatibility complex) class II-mediated immune responses, where CTSS degrades Ii (type II membrane glycoprotein invariant chain) sequence of MHC II aβ heterodimers. Ii contains signaling motifs and its degradation leads to successful association of class II associated invariant chain peptide (CLIP) with the peptide groove of the MHC class II molecule. This is essential for antigen loading on MHC II complex during antigen presentation. Overexpression of this protein in mice leads to increased proteinase-activated receptor-2 (PAR-2) expression in dendritic cells resulting in scratching behavior and Th1 (T-helper) cell-associated cytokine expression. This can eventually lead to chronic atopic dermatitis in mice.
Stato fisico
A 0.2 μM filtered solution of 20mM MES, 150mM NaCl, 10% Glycerol, pH 5.5.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.
Possiedi già questo prodotto?
I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Sarah F Hamm-Alvarez et al.
Arthritis & rheumatology (Hoboken, N.J.), 66(7), 1872-1881 (2014-03-20)
The diagnosis of Sjögren's syndrome (SS) in routine practice is largely a clinical one and requires a high index of suspicion by the treating physician. This great dependence on clinical judgment frequently leads to delayed diagnosis or misdiagnosis. Tear protein
Si-Tu Xue et al.
RSC advances, 9(15), 8600-8607 (2019-03-14)
Cathepsin K (Cat K) is a predominant cysteine protease and highly potent collagenase expressed in osteoclasts. Cat K inhibitors are anti-resorptive agents to treat osteoporosis. A novel scaffold of cathepsin K inhibitors, exemplified by lead compound 1x, was used as
Nari Kim et al.
The Journal of investigative dermatology, 132(4), 1169-1176 (2011-12-16)
Atopic dermatitis (AD) is a chronically relapsing, non contagious pruritic skin disease with two phases: acute and chronic. Cysteine protease cathepsin S (CTSS) is involved in inflammatory processes, possibly leading to atherosclerosis and asthma. Recently, it has been reported that
Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..
Contatta l'Assistenza Tecnica.