SRP0115
Sirtuin 1 human
recombinant, expressed in E. coli, ≥60% (SDS-PAGE)
Sinonimo/i:
SIR2, SIRT1, Sir2A, sir2-like 1
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About This Item
Codice UNSPSC:
12352200
NACRES:
NA.32
Prodotti consigliati
Origine biologica
human
Ricombinante
expressed in E. coli
Saggio
≥60% (SDS-PAGE)
Forma fisica
aqueous solution
PM
87.2 kDa
Confezionamento
pkg of 100 μg
Condizioni di stoccaggio
avoid repeated freeze/thaw cycles
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
dry ice
Temperatura di conservazione
−70°C
Informazioni sul gene
human ... SIRT1(23411)
Descrizione generale
Human Sirtuin 1, GenBank Accession No. NM_012238), amino acids 193-741 with N-terminal ST tag, MW = 87.2 kDa, expressed in E. coli expression system.
Applicazioni
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Definizione di unità
One unit is defined as the amount of enzyme required to deacetylate 1 pmol of substrate/min at 37°C.
Stato fisico
Formulated in 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20 and 20% glycerol.
Nota sulla preparazione
Thaw on ice. Upon first thaw, briefly spin tube containing enzyme to recover full content of the tube. Aliquot enzyme into single use aliquots. Store remaining undiluted enzyme in aliquots at -70°C. Note: Enzyme is very sensitive to freeze/thaw cycles.
Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.
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[SIRT1].
Hattori Y and Ihara M.
Nihon Rinsho. Japanese Journal of Clinical Medicine, 74(4), 589-594 (2016)
SIRT 1 Overexpression is Associated with Metastasis of Pancreatic Ductal Adenocarcinoma (PDAC) and Promotes Migration and Growth of PDAC Cells.
Li S, et al.
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 22, 1593-1600 (2016)
Wen-Li Mu et al.
Stem cells (Dayton, Ohio), 33(7), 2135-2147 (2015-05-06)
Mouse somatic cells can be reprogrammed into induced pluripotent stem cells by defined factors known to regulate pluripotency, including Oct4, Sox2, Klf4, and c-Myc. Together with Oct4, Sox2 plays a major role as a master endogenous pluripotent genes trigger in
Yanxiang Li et al.
The Journal of nutritional biochemistry, 26(11), 1338-1347 (2015-08-25)
Nicotinic acid (NA) has recently been shown to inhibit inflammatory response in cardiovascular disease. Sirtuin1 (SIRT1), a NAD(+)-dependent class III histone deacetylase, participates in the regulation of cellular inflammation. We hypothesized that dietary supplementation of NA could attenuate vascular inflammation
Yun H Kim et al.
Vascular pharmacology, 72, 35-42 (2015-05-15)
Silent mating type information regulation 2 homolog 1 (SIRT1) is known as a key regulator in the protection of various vascular disorders, however, no direct evidences have been reported in the progression of atherosclerosis. Considering the pivotal role of matrix
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