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Merck
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Documenti

SML1376

Sigma-Aldrich

BTC

≥95% (HPLC)

Sinonimo/i:

2-(4-Hydroxyphenyl)-1-benzothiophene-6-ol, 2-(4-Hydroxyphenyl)benzo[b]thiophene-6-ol

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About This Item

Formula empirica (notazione di Hill):
C14H10O2S
Numero CAS:
63676-22-2
Peso molecolare:
242.29
Codice UNSPSC:
51111800
NACRES:
NA.77

Saggio

≥95% (HPLC)

Forma fisica

powder

Condizioni di stoccaggio

protect from light

Colore

white to light brown

Solubilità

DMSO: 20 mg/mL, clear

Temperatura di conservazione

−20°C

InChI

1S/C14H10O2S/c15-11-4-1-9(2-5-11)13-7-10-3-6-12(16)8-14(10)17-13/h1-8,15-16H
MDGWZLQPNOETLH-UHFFFAOYSA-N

Azioni biochim/fisiol

BTC is a selective estrogen receptor (ER) modulator (SERM) that acts as a selective estrogen mimic (SEM). BTC has been found to be both estrogenic and antiproliferative in ER-positive endocrine-resistant breast cancer cell lines that overexpress protein kinase C alpha (PKCα), which is often associated with tamoxifen resistance. BTC caused regression of endocrine-resistant breast cancer xenografts, and did not support the growth of hormone-dependent xenografts in vivo or cause an increase in uterine weight. As in the case with raloxifene and estradiol, BTC tumor regression was accompanied by the exit of ERα from the nucleus, suggesting extranuclear ERα may be involved in the mehanism of action.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302

Consigli di prudenza

P301 + P312 + P330

Classi di pericolo

Acute Tox. 4 Oral

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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Jibin An et al.
Environmental research, 191, 110067-110067 (2020-08-21)
Metal-organic frameworks (MOFs) are emerging class of porous materials that attracted tremendous attention as eco-friendly photocatalysts. However, poor charge separation in most MOFs largely thwarts their photocatalytic performance. In this work, Materials of Institut Lavoisier-100(Fe) (MIL-100 (Fe)) based on iron
Ho-Young Jang et al.
Environmental pollution (Barking, Essex : 1987), 267, 115583-115583 (2020-12-02)
In this study, a metal organic framework MIL-100(Fe) was synthesized for rhodamine B (RB) removal from aqueous solutions. An experimental design was conducted using a central composite design (CCD) method to obtain the RB adsorption data (n = 30) from batch experiments.
Xiaozhou Huang et al.
Analytical and bioanalytical chemistry, 412(4), 849-860 (2020-01-04)
In this paper, a novel bimetallic Ce-Ni metal-organic frameworks (Ce-Ni-MOF) are synthesized by hydrothermal reaction, using 1,3,5-benzenetricarboxylic acid as a ligand. In particular, the bimetallic Ce-Ni-MOF with the largest specific surface area and catalytic sites was synthesized when the molar
Axel X Canatelli et al.
ChemPlusChem, 85(10), 2349-2356 (2020-10-24)
Metal-organic frameworks (MOFs) are known for their versatility in terms of their crystalline structure, porosity, resistance to temperature, radiation damage, and luminescence among others. Gadolinium (Gd) is one of the elements with the highest reported cross-section for low energy neutron
Rui Pei et al.
Journal of hazardous materials, 384, 121418-121418 (2019-12-11)
Three-dimensional (3D) printing technique has received exceptional global attention as it can create a myriad of high-resolution architectures from digital models. In the present study, 3D-printed metal-organic frameworks (MOFs) were shaped into several geometries via direct ink writing, which overcomes
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