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SML0517

Sigma-Aldrich

Amlexanox

≥98% (HPLC)

Sinonimo/i:

2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]Benzopyrano[2,3-b]pyridine-3-carboxylic acid, AA 673, Amoxanox, CHX 3673

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CHF 111.00
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CHF 443.00

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10 MG
CHF 111.00
50 MG
CHF 443.00

About This Item

Formula empirica (notazione di Hill):
C16H14N2O4
Numero CAS:
68302-57-8
Peso molecolare:
298.29
Numero MDL:
MFCD00864790
Codice UNSPSC:
12352200
ID PubChem:
329825526
NACRES:
NA.77

CHF 111.00

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Saggio

≥98% (HPLC)

Stato

powder

Colore

white to beige

Solubilità

DMSO: 10 mg/mL at warmed, clear

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

Stringa SMILE

CC(C)c1ccc2Oc3nc(N)c(cc3C(=O)c2c1)C(O)=O

InChI

1S/C16H14N2O4/c1-7(2)8-3-4-12-9(5-8)13(19)10-6-11(16(20)21)14(17)18-15(10)22-12/h3-7H,1-2H3,(H2,17,18)(H,20,21)
SGRYPYWGNKJSDL-UHFFFAOYSA-N

Informazioni sul gene

human ... PDE4A(5141) , PDE4B(5142) , PDE4C(5143) , PDE4D(5144)

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Descrizione generale

Amlexanox is an anti-allergic drug with anti-inflammatory properties.[1]

Azioni biochim/fisiol

Amlexanox elevates the amount of nonsense-containing mRNAs in treated cells and helps to generate full-length proteins effectively.[1]
Amlexanox is an anti-allergy and anti-asthma drug that blocks histamine and leukotriene release from leukocytes and mast cells. Amlexanox has also been shown to inhibit cahaperone activity of Hsp90, and S100A13, which is involved in transport of proteins devoid of signal peptide sequences.
Amlexanox is an anti-allergy, anti-ulcer drug; S100A13 inhibitor.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302

Classi di pericolo

Acute Tox. 4 Oral

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
0000390398
0000383510
0000390398
0000383510
0000163464

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Sigma-Aldrich

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Influenza Hemagglutinin (HA) Peptide ≥97% (HPLC)

Sigma-Aldrich

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Sigma-Aldrich

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Sigma-Aldrich

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Sandhya G Rani et al.
Biochemistry, 49(11), 2585-2592 (2010-02-25)
S100A13 and acidic fibroblast growth factor (FGF1) are involved in a wide array of important biological processes, such as angiogenesis, cell differentiation, neurogenesis, and tumor growth. Generally, the biological function of FGF1 is to recognize a specific tyrosine kinase on
Nesrine Benslimane et al.
Pharmaceuticals (Basel, Switzerland), 16(7) (2023-07-29)
Nonsense mutations are involved in multiple peripheral neuropathies. These mutations induce the presence of a premature termination codon (PTC) at the mRNA level. As a result, a dysfunctional or truncated protein is synthesized, or even absent linked to nonsense-mediated mRNA
Brenda Murray et al.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 34(7), 413-419 (2005-07-14)
Recurrent minor aphthous ulceration (RAU) is a common condition which is multifactorial in origin. This study, firstly, aimed to treat the prodromal stage of RAU with Aphtheal (5% amlexanox paste) to determine if ulcer development could be prevented. A second
Dakshinamurthy Rajalingam et al.
Biochemistry, 44(47), 15472-15479 (2005-11-23)
Fibroblast growth factor (FGF-1) lacks a signal sequence and is exported by an unconventional release mechanism. The nonclassical export of FGF-1 has been shown to be inhibited by an anti-allergic and anti-inflammatory drug, amlexanox (AMX). We investigate the molecular mechanism(s)
F Tarantini et al.
The Journal of biological chemistry, 276(7), 5147-5151 (2000-11-23)
Interleukin (IL)1alpha mediates proinflammatory events through its extracellular interaction with the IL1 type I receptor. However, IL1alpha does not contain a conventional signal peptide sequence that provides access to the endoplasmic reticulum-Golgi apparatus for secretion. Thus, we have studied the
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