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SML0208

Sigma-Aldrich

KYP-2047

≥95% (HPLC)

Sinonimo/i:

(2S)-1-[[(2S)-1-(1-Oxo-4-phenylbutyl)-2-pyrrolidinyl]carbonyl]-2-pyrrolidinecarbonitrile

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5 MG
CHF 171.00
25 MG
CHF 597.00

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5 MG
CHF 171.00
25 MG
CHF 597.00

About This Item

Formula empirica (notazione di Hill):
C20H25N3O2
Numero CAS:
796874-99-2
Peso molecolare:
339.43
Numero MDL:
MFCD22201003
Codice UNSPSC:
12352200
ID PubChem:
329825230
NACRES:
NA.77

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Saggio

≥95% (HPLC)

Stato

oil

Condizioni di stoccaggio

desiccated

Colore

white to light brown

Temperatura di conservazione

2-8°C

Stringa SMILE

O=C(CCCc1ccccc1)N2CCC[C@H]2C(=O)N3CCC[C@H]3C#N

InChI

1S/C20H25N3O2/c21-15-17-10-5-13-22(17)20(25)18-11-6-14-23(18)19(24)12-4-9-16-7-2-1-3-8-16/h1-3,7-8,17-18H,4-6,9-14H2/t17-,18-/m0/s1
SPXFAUXQZWJGCJ-ROUUACIJSA-N

Applicazioni

KYP-2047 may be used in prolyl endopeptidase-mediated cell signaling studies.

Azioni biochim/fisiol

KYP-2047 clears the α-synuclein aggregates induced by oxidative stress in the neuronal cells. α-synuclein is the main component of Lewy bodies in Parkinson′s disease that cause neuronal cell death and dementia.[1]
KYP-2047 is a very potent, selective inhibitor of Prolyl oligopeptidase (POP), also known as prolyl endopeptidase (PEP or PE). Ki = .023nM (porcine).
KYP-2047 is a very potent, selective inhibitor of Prolyl oligopeptidase (POP), also known as prolyl endopeptidase (PEP or PE). Ki = .023nM (porcine). KYP-2047 has been found to be neuroprotective against glutamate and oxygen, glucose deprivation in vitro. It has also been used to inhibit the formation of AcSDKP from its precursor 43-mer thymosin β4 (Tβ4). Ac-SDKP is involved in hemopoietic stem cell differentiation, is pro-angiogenic and antifibrogenic.

Caratteristiche e vantaggi

This compound is featured on the Neuropeptidases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H319

Classi di pericolo

Eye Irrit. 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
0000289195
0000230086
032M4606V

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Yuki Maruyama et al.
Placenta, 53, 8-15 (2017-05-11)
Prolyl oligopeptidase (prolyl endopeptidase, Prep), a multifunctional protease hydrolyzing -Pro-X- peptide bonds, is highly expressed in the mouse placenta, but the function during development is not known. We explored the possibility of Prep's involvement in placental differentiation. We cultured trophoblast
Giovanna Casili et al.
Oncotarget, 12(17), 1663-1676 (2021-08-27)
Intestinal ischemia-reperfusion (II/R) develops when the blood flow to the intestines decreases, followed by the reestablishment of the blood supply to the ischemic tissue, resulting in intestinal mucosal barrier dysfunction, with consequent severe local and systemic inflammation. Acute lung injury
Reinis Svarcbahs et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(49), 12485-12497 (2016-12-09)
Decreased clearance of α-synuclein (aSyn) and aSyn protein misfolding and aggregation are seen as major factors in the pathogenesis of Parkinson's disease (PD) and other synucleinopathies that leads to disruption in neuronal function and eventually to cell death. Prolyl oligopeptidase
Jianbin Zhang et al.
Life sciences, 270, 119131-119131 (2021-02-01)
Prolyl endopeptidase (PREP) is a serine endopeptidase widely distributed in the body, and accumulated evidence suggests that PREP participates in inflammation and oxidative stress. Here, we explored the effect of PREP gene disruption on hepatic inflammation and oxidative stress status
T T Myöhänen et al.
British journal of pharmacology, 166(3), 1097-1113 (2012-01-12)
The aggregation of α-synuclein is connected to the pathology of Parkinson's disease and prolyl oligopeptidase (PREP) accelerates the aggregation of α-synuclein in vitro. The aim of this study was to investigate the effects of a PREP inhibitor, KYP-2047, on α-synuclein
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