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Merck
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Documenti

SML0087

Sigma-Aldrich

MEGX

≥95% (HPLC)

Sinonimo/i:

MGEX, Monoethylglycinexylidide, N-(2,6-dimethylphenyl)-2-(ethylamino)acetamide, Norlidocaine

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About This Item

Formula empirica (notazione di Hill):
C12H18N2O
Numero CAS:
7728-40-7
Peso molecolare:
206.28
Numero MDL:
MFCD00098991
Codice UNSPSC:
12352200
ID PubChem:
329825147
NACRES:
NA.77

Saggio

≥95% (HPLC)

Forma fisica

powder

Condizioni di stoccaggio

desiccated

Colore

white to beige

Solubilità

H2O: 10 mg/mL, clear

Temperatura di conservazione

2-8°C

Stringa SMILE

CC1=C(NC(CNCC)=O)C(C)=CC=C1

InChI

1S/C12H18N2O/c1-4-13-8-11(15)14-12-9(2)6-5-7-10(12)3/h5-7,13H,4,8H2,1-3H3,(H,14,15)
WRMRXPASUROZGT-UHFFFAOYSA-N

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Categorie correlate

Applicazioni

MEGX has been used in an approach to improve the yield of N-dealkylated lidocaine.

Azioni biochim/fisiol

MEGX is generated by hepatic cytochrome P-450 system upon oxidative de-ethylation. Measurement of MEGX by immunoassay contributes to liver function test. MEGX possesses antiarrhythmic action and therefore extends lidocaine effect.
Monoethylglycinexylidide (MEGX) is an active metabolite of lidocaine.

Pittogrammi

Skull and crossbones
GHS06

Avvertenze

Danger

Indicazioni di pericolo

H301

Classi di pericolo

Acute Tox. 3 Oral

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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E J Dickey et al.
Equine veterinary journal, 40(4), 348-352 (2008-02-13)
Continuous-rate infusions (CRI) of lidocaine are often used for prolonged duration but, to date, only limited time/concentration relationships administered as a short term (24 h) CRI have been reported. To determine the time/concentration profile of lidocaine and its active metabolites
Elaine Christine Dantas Moisés et al.
European journal of clinical pharmacology, 64(12), 1189-1196 (2008-08-06)
Peridural blockade with lidocaine, bupivacaine, and fentanyl is an anesthetic procedure extensively used in obstetrics, justifying the pharmacokinetic study of these drugs during labor. To investigate the influence of the physiopathological changes of gestational diabetes mellitus (GDM) on the pharmacokinetics
K Rolsted et al.
Skin pharmacology and physiology, 22(3), 124-127 (2009-01-13)
Little is known about the metabolising capacity of the human skin in relation to topically applied drugs and formulations. We chose lidocaine as a model compound since the metabolic pathways are well known from studies concerning hepatic metabolism following systemic
Ying Wang et al.
Drug design, development and therapy, 14, 1739-1747 (2020-05-23)
Lidocaine has cardiovascular and neurologic toxicity, which is dose-dependent. Due to CYP3A4-involved metabolism, lidocaine may be prone to drug-drug interactions. Given statins have the possibility of combination with lidocaine in the clinic, we established in vitro models to assess the
Optimization of reaction parameters for the electrochemical oxidation of lidocaine with a Design of Experiments approach
Gul T, et al.
Electrochimica Acta, 171, 23-28 (2015)
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