SAB5900404

Anti-Monkeypox virus/MPXV E8L Antibody (SAA0285)

• Sinonimo/i: E8L, Cell surface-binding protein, Carbonic anhydrase homolog, Monkeypox virus (MPXV)
• Codice UNSPSC: 12352203

Proprietà

• Origine biologica: mouse
• Livello qualitativo: 100
• Ricombinante: expressed in CHO cells
• Coniugato: unconjugated
• Forma dell’anticorpo: affinity purified immunoglobulin
• Clone: SAA0285, recombinant monoclonal
• Saggio: >95% (SDS-PAGE)
• Forma fisica: liquid
• PM: 150 kDa
• Reattività contro le specie: monkeypox virus
• Concentrazione: 1 mg/mL
• tecniche: ELISA: 1:2000-1:4000; neutralization: 0.01-10 μg/mL
• Colore: colorless
• pH: 7.4
• Isotipo: IgG2a, kappa
• N° accesso ID proteina: NP_536532.1
• N° accesso UniProt: Q8V4Y0
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: -65 to -96°C
• modifica post-traduzionali bersaglio: unmodified

Descrizione

Descrizione generale

Anti-Monkeypox virus/MPXV E8L Antibody, clone SAA0285, is a hybrid protein of mouse and human origin, consisting of a single light chain and a single heavy chain. The light chain is composed of a variable region (VL) and a constant region (CL) while the heavy chain is composed of a variable region (VH) and a constant region (CH). The VL and VH regions are responsible for the binding of the antibody to the antigens on the Monkeypox virus, while the CL and CH regions are responsible for the production of anti-viral proteins.
Monkeypox virus (MPXV), like smallpox virus, belongs to the genus Orthopoxvirus. Its morphology is consistent with that of orthopoxvirus, with a brick-shaped or oval shape with rounded corners and a size of 200~400nm. Brick-shaped or oval-shaped, covered by a lipoprotein membrane or envelope, with two protein-containing side bodies in the middle, and a thick membrane core containing a large double-stranded DNA gene body. The genome of Mpox virus is a double-stranded DNA, about 197kb long, and the end of the genome contains an identical but opposite terminal inverted repeat sequence. The virus contains 190 open reading frames, 4 of which are located in terminal inverted repeats. The core proteins of monkeypox virus are A29L, A35R, B6R, M1R, H3L.

Specificità

Monoclonal Anti-Monkeypox virus/MPXV E8L Antibody, clone SAA0285 binds to the antigens on the surface of the Monkeypox virus, blocking the virus from entering host cells. It also activates the production of anti-viral proteins, which neutralize the virus and inhibit its replication. The antibody also activates the immune system, helping to clear the virus from the body.

Applicazioni

ELISA,neutralization

Confezionamento

100µg per vial / 1 mg per vial

Stoccaggio e stabilità

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.Store at +4°C short term (1-2 weeks).Store at -20 °C 12 months. Store at -80°C long term.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable