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SAB5200080

Sigma-Aldrich

Monoclonal Anti-ITPR1 antibody produced in mouse

clone S24-18, 1 mg/mL, purified immunoglobulin

Sinonimo/i:

Anti-IP3 Receptor

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100 μG
CHF 427.00

CHF 427.00

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100 μG
CHF 427.00

About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

CHF 427.00

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Origine biologica

mouse

Livello qualitativo

100

Coniugato

unconjugated

Forma dell’anticorpo

purified immunoglobulin

Tipo di anticorpo

primary antibodies

Clone

S24-18, monoclonal

Stato

buffered aqueous glycerol solution

PM

antigen predicted mol wt 300 kDa

Reattività contro le specie

human, mouse, rat

Concentrazione

1 mg/mL

tecniche

immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

Isotipo

IgG1

N° accesso NCBI

NP_001007236.1

N° accesso UniProt

Q14643

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

rat ... Itpr1(25262)

Descrizione generale

Inositol 1,4,5-trisphosphate receptor, type 1 (ITPR1) is highly expressed in the rat brain and is also seen in the heart. It possesses an inositol-triphosphate binding domain, a channel-forming region and a regulatory region. ITPR1 is composed of 2749 amino acids. The gene ID for the protein is 25262.

Specificità

Detects ~300 kDa. Does not recognize type 2 or type 3 IP3R′s.

Immunogeno

Fusion protein amino acids 2680-2749 (cytoplasmic carboxyl terminus) of rat type1 IP3R inositol 1,4,5-triphosphate receptor type 1, Itpr1

Applicazioni

Monoclonal Anti-ITPR1 antibody produced in mouse has been used for Western blotting.

Azioni biochim/fisiol

Inositol 1,4,5-trisphosphate receptor, type 1 (ITPR1) takes part in Ca2+ signaling on binding to its ligand, inositol 1,4,5-trisphosphate.

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Stato fisico

Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
1011

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Krishna P Subedi et al.
Cellular & molecular biology letters, 17(1), 124-135 (2011-12-31)
Inositol 1,4,5-trisphosphate receptor type 1 (IP(3)R1) is already known to be highly expressed in the brain, and is found in many other tissues, including the atrium of the heart. Although the complete primary structure of IP(3)R1 in the rat brain
Yi Sun et al.
The Biochemical journal, 449(1), 39-49 (2012-09-27)
Binding of IP3 (inositol 1,4,5-trisphosphate) to the IP3-binding core (residues 224-604) of IP3Rs (IP3 receptors) initiates opening of these ubiquitous intracellular Ca2+ channels. The mechanisms are unresolved, but require conformational changes to pass through the suppressor domain (residues 1-223). A
Calcium signalling from the type I inositol 1,4,5-trisphosphate receptor is required at early phase of liver regeneration.
Oliveira AG
Liver International : Official Journal of the International Association For the Study of the Liver, 35(4), 1162-1171 (2015)
Hong Wang et al.
Toxicology, 333, 137-146 (2015-04-30)
Previous studies have shown that cytosolic Ca(2+) ([Ca(2+)]c) overload was involved in Pb-induced apoptosis in primary cultures of rat proximal tubular (rPT) cells, but the source of elevated Ca(2+) and the effect of potential subcellular Ca(2+) redistribution on apoptosis are

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