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SAB4700267

Sigma-Aldrich

Monoclonal Anti-CD64 antibody produced in mouse

clone 10.1, purified immunoglobulin, buffered aqueous solution

Sinonimo/i:

Anti-FCGR1, Anti-FcγRI

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100 μG
CHF 216.00

CHF 216.00


Spedizione prevista il24 aprile 2025



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Cambia visualizzazione
100 μG
CHF 216.00

About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

CHF 216.00


Spedizione prevista il24 aprile 2025


Origine biologica

mouse

Livello qualitativo

Coniugato

unconjugated

Forma dell’anticorpo

purified immunoglobulin

Tipo di anticorpo

primary antibodies

Clone

10.1, monoclonal

Stato

buffered aqueous solution

Reattività contro le specie

human, nonhuman primates

Concentrazione

1 mg/mL

tecniche

flow cytometry: suitable

Isotipo

IgG1

N° accesso NCBI

Condizioni di spedizione

wet ice

Temperatura di conservazione

2-8°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... FCGR1(2209)

Descrizione generale

The mouse monoclonal antibody 10.1 recognizes alpha subunit of CD64/FcgammaRI, a 72 kDa single chain type I glycoprotein, that is expressed on monocytes/macrophages, dendritic cells, and activated granulocytes.

Immunogeno

Rheumatoid synovial fluid cells and fibronectin purified human monocytes

Applicazioni

Cluster of differentiation 64 (CD64) has been implicated in various immunological processes such as phagocytosis, the clearance of immune complexes and the secretion of immunological mediators. In addition, it also facilitates antibody-dependent cellular cytotoxicity, the modulation of B-cell differentiation and transcytosis of IgG across the epithelial layer. Neutrophil CD64 serves as a potent diagnostic marker for bacterial infection and neonatal sepsis.

Azioni biochim/fisiol

The cluster of differentiation 64 (CD64), also known as Fc fragment of IgG receptor Ia (FCGR1A), gene is mapped to human chromosome lq21.2--q21.3. The gene codes for a 72 kDa glycoprotein that is constitutively expressed on human monocytes and macrophages.

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Stato fisico

Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


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Neutrophil CD64 as a diagnostic marker for neonatal sepsis: Meta-analysis.
Dai J, et al.
Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University, 327-332 (2017)
Neutrophil CD64 expression as a longitudinal biomarker for severe disease and acute infection in critically ill patients.
Jong E, et al.
International Journal of Laboratory Hematology, 38(5), 576-584 (2016)
Human high-affinity Fc?RI (CD64) gene mapped to chromosome 1q21.2-q21.3 by fluorescence in situ hybridization
Takai S, et al.
Human Genetics, 93(1), 13-15 (1994)
Yunqin Lee et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 22(14), 3571-3581 (2016-02-13)
Human tumors consist of heterogeneous populations of cells with distinct marker expression and functional properties. In squamous cell carcinoma of the head and neck (SCCHN), CD44 is a well-characterized marker of a resilient subpopulation of cells associated with increased tumorigenesis

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