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SAB4502446

Sigma-Aldrich

Anti-CXCR7 antibody produced in rabbit

affinity isolated antibody

Sinonimo/i:

CXCR-7, CXCR7, G-protein coupled receptor 159, G-protein coupled receptor RDC1, chemokine orphan receptor 1

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

antigen 41 kDa

Reattività contro le specie

rat, mouse, human

Concentrazione

~1 mg/mL

tecniche

ELISA: 1:1000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000

N° accesso NCBI

P25106

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... CXCR7(57007)

Descrizione generale

Anti-CXCR7 Antibody detects endogenous levels of total CXCR7 protein.
CXC- Chemokine receptor 7 (CXCR7) protein is a seven-transmembrane G-protein coupled receptor (GPCR). It is expressed in the heart tissues, fetal hematopoietic cells, embryonic neuronal, and activated endothelium. CXCR7 gene is mapped on the human chromosome at 2q37.3.

Immunogeno

The antiserum was produced against synthesized peptide derived from human CXCR7.

Immunogen Range: 311-360

Azioni biochim/fisiol

CXC- Chemokine receptor 7 (CXCR7) protein interacts with chemokine ligands CXCL11 and CXCL12. This protein shuffles between the plasma membrane and endosomal compartments irrespective of the presence of a ligand such as CXCL11 and 12. CXCR7 protein plays a role in cell survival and cell adhesion to the endothelium. This protein tends to regulate the activity of CXCR4.

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Stato fisico

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

nwg

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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Lorena Sánchez-Martín et al.
Trends in molecular medicine, 19(1), 12-22 (2012-11-17)
It is known that the chemokine receptor CXCR7 (RDC1) can be engaged by both chemokines CXCL12 (SDF-1) and CXCL11 (I-TAC), but the exact expression pattern and function of CXCR7 is controversial. CXCR7 expression seems to be enhanced during pathological inflammation
Angélique Levoye et al.
Blood, 113(24), 6085-6093 (2009-04-22)
The stromal cell-derived factor-1/CXCL12 chemokine engages the CXCR4 and CXCR7 receptors and regulates homeostatic and pathologic processes, including organogenesis, leukocyte homeostasis, and tumorigenesis. Both receptors are widely expressed in mammalian cells, but how they cooperate to respond to CXCL12 is
Ulrike Naumann et al.
PloS one, 5(2), e9175-e9175 (2010-02-18)
CXCR7 (RDC1), the recently discovered second receptor for CXCL12, is phylogenetically closely related to chemokine receptors, but fails to couple to G-proteins and to induce typical chemokine receptor mediated cellular responses. The function of CXCR7 is controversial. Some studies suggest

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