Passa al contenuto
Merck
Tutte le immagini(1)

Documenti fondamentali

SAB4502163

Sigma-Aldrich

Anti-Mucin-14 antibody produced in rabbit

affinity isolated antibody

Sinonimo/i:

Endomucin, Endomucin-2, Gastric cancer antigen Ga34, MUC-14, Mucin-14

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Tutte le immagini(1)

About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Livello qualitativo

100

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Stato

buffered aqueous solution

PM

antigen 27 kDa

Reattività contro le specie

human, rat, mouse

Concentrazione

~1 mg/mL

tecniche

ELISA: 1:1000
immunofluorescence: 1:100-1:500

N° accesso NCBI

Q9ULC0

N° accesso UniProt

Q9ULC0

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... EMCN(51705)

Descrizione generale

The EMCN (endomucin) gene is mapped to human chromosome 4q24. It encodes a 80−120kDa transmembrane sialomucin. Mucin-14 is predominantly expressed in heart, kidney and lungs. Endomucin is a surface glycoprotein localized to the endothelial cells. Mucin-14 is a type 1 integral protein. Endomucin possesses 261 amino acid residues and a serine/threonine-rich extracellular domain. Anti-Mucin-14 Antibody detects endogenous levels of total Mucin-14 protein.

Immunogeno

The antiserum was produced against synthesized peptide derived from human Mucin-14.

Immunogen Range: 201-250

Azioni biochim/fisiol

Mucin-14 controls lymphocyte adhesion and its expression is associated with the pathogenesis of rheumatoid arthritis. Mucin-14 associated with O-glycans enables it to promote cell−matrix and cell-cell interactions.

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Stato fisico

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Non trovi il prodotto giusto?  

Prova il nostro Motore di ricerca dei prodotti.

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

nwg

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Scegli una delle versioni più recenti:

Certificati d'analisi (COA)

Lot/Batch Number
3111879

Non trovi la versione di tuo interesse?

Se hai bisogno di una versione specifica, puoi cercare il certificato tramite il numero di lotto.

Cerca un COA

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

Endomucin inhibits VEGF-induced endothelial cell migration, growth, and morphogenesis by modulating VEGFR2 signaling
Park WC, et al.
Scientific reports, 7(1), 17138-17138 (2017)
A Novel Acquired t (2; 4)(q36. 1; q24) with a Concurrent Submicroscopic del (4)(q23q24) in An Adult with Polycythemia Vera
Kjeldsen E
Cancers, 10(7), 214-214 (2018)
Alisar Zahr et al.
Nature communications, 7, 10363-10363 (2016-02-03)
Endomucin is a membrane-bound glycoprotein expressed luminally by endothelial cells that line postcapillary venules, a primary site of leukocyte recruitment during inflammation. Here we show that endomucin abrogation on quiescent endothelial cells enables neutrophils to adhere firmly, via LFA-1-mediated binding
Kazumasa Nishimoto et al.
The Journal of rheumatology, 38(2), 221-228 (2010-12-17)
Endomucin, an endothelial-specific sialomucin, is thought to facilitate "lymphocyte homing" to synovial tissues, resulting in the major histopathologies of rheumatoid arthritis (RA). We examined the association between RA susceptibility and the gene coding endomucin, EMCN. Association studies were conducted with

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.