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Documenti fondamentali

SAB4501137

Sigma-Aldrich

Anti-Glucagon antibody produced in rabbit

affinity isolated antibody

Sinonimo/i:

Glicentin, Glicentin-related polypeptide, Glucagon-like peptide 1(7-37), Glucagon-like peptide 1(GLP-1), Oxyntomodulin

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100 μG
CHF 456.00

CHF 456.00


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100 μG
CHF 456.00

About This Item

Numero MDL:
Codice UNSPSC:
12352203
NACRES:
NA.41

CHF 456.00


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Origine biologica

rabbit

Livello qualitativo

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Stato

buffered aqueous solution

PM

antigen 20 kDa

Reattività contro le specie

human, rat, mouse

Concentrazione

~1 mg/mL

tecniche

ELISA: 1:5000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000

N° accesso NCBI

N° accesso UniProt

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... GCG(2641)

Descrizione generale

Anti-Glucagon antibody detects endogenous levels of total Glucagon protein.
Glucagon-like peptide-1 (GLP-1) is a gastrointestinal hormone. It is a 30-amino acid peptide, that is generated by the intestinal epithelial endocrine L-cells. it is mapped to human chromosome 2q24.

Immunogeno

The antiserum was produced against synthesized peptide derived from human Glucagon.

Immunogen Range: 61-110

Applicazioni

Anti-glucagon antibody has been used in immunostaining and immunohistochemistry.[1]
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)

Azioni biochim/fisiol

Glucagon-like peptide-1 (GLP-1) increases glucose-dependent insulin secretion and terminates the liberation of glucagon. It acts as a physiological regulator of appetite and food intake. GLP-1 also helps to prevent the gastrointestinal movement and secretion.

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Stato fisico

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

nwg

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


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The Physiology of Glucagon-like Peptide 1
Holst JJ
American Physiological Society, 87(4), 1409-1439 (2007)
Maria Eriksson et al.
Molecular pharmaceutics, 18(12), 4428-4436 (2021-10-16)
Type 1 diabetes develops in childhood and adolescence, with peak incidence in the early teenage years. There is an urgent need for an accurate method to detect insulin-producing β-cells in patients that is not affected by alterations in β-cell function.
Reg3? Overexpression Protects Pancreatic Beta-Cells From Cytokine-Induced Damage and Improves Islet Transplant Outcome
Ding Y, et al.
Molecular Medicine, 20(1), 548-548 (2014)
Glucagon-like Peptide-1 Analogues Inhibit Proliferation and Increase Apoptosis of Human Prostate Cancer Cells in vitro
Li XN, et al.
Experimental and Clinical Endocrinology & Diabetes, 125(02), 91-97 (2017)
Expression and regulation of chemokines in murine and human type 1 diabetes
Sarkar SA, et al.
Diabetes, 61(2), 436-446 (2012)

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