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Merck
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Key Documents

SAB4300102

Sigma-Aldrich

Anti-phospho-AKT2 (pSer474) antibody produced in rabbit

affinity isolated antibody

Sinonimo/i:

Anti-PKBB antibody produced in rabbit, Anti-PKBBETA antibody produced in rabbit, Anti-PRKBB antibody produced in rabbit, Anti-RAC-BETA antibody produced in rabbit, Anti-v-akt murine thymoma viral oncogene homolog 2 antibody produced in rabbit

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About This Item

Numero MDL:
MFCD01633020
Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

~60 kDa

Reattività contro le specie

human, rat, mouse

Concentrazione

1 mg/mL

tecniche

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
western blot: 1:500-1:1000

Isotipo

IgG

Sequenza immunogenica

(Q-F-SP-Y-S)

N° accesso NCBI

NP_001617.1

N° accesso UniProt

P31751

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

phosphorylation (pSer474)

Informazioni sul gene

human ... AKT2(208)

Immunogeno

Peptide sequence around phosphorylation site of serine 474 (Q-F-S(p)-Y-S), according to the protein AKT2.

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Descrizione del bersaglio

General protein kinase capable of phosphorylating several known proteins.

Stato fisico

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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Alberto Bavelloni et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(8), 9044-9061 (2019-05-17)
Murine thymoma viral oncogene homolog (AKT) kinases target both cytosolic and nuclear substrates for phosphorylation. Whereas the cytosolic substrates are known to be closely associated with the regulation of apoptosis and autophagy or metabolism and protein synthesis, the nuclear substrates
Daolu Yuwen et al.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 28(1), 163-173 (2018-09-20)
Platinum-based doublets with a third-generation agent are the recommended option for many patients with non-small cell lung cancer (NSCLC) with no contraindications to platinum compounds. Unfortunately, the clinical effectiveness of such chemotherapy is limited by intrinsic or acquired resistance. Circulating
K Soukupová et al.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 52, 58-67 (2019-02-09)
The specific effects of sodium selenite (selenite) on a chemoresistant human bladder cancer cell line RT-112/D21 were investigated during 72 h. Selenite at low concentration of 2.5 μmol (otherwise tolerated in normal urothelial cells UROtsa) suppressed growth and proliferation of the tested

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