SAB4200806

Anti-Ezrin antibody, Mouse monoclonal

clone 3C12, purified from hybridoma cell culture

• Sinonimo/i: Cytovillin, Villin-2, p81
• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: mouse
• Forma dell’anticorpo: purified from hybridoma cell culture
• Tipo di anticorpo: primary antibodies
• Clone: 3C12, monoclonal
• Forma fisica: buffered aqueous solution
• PM: ~80 kDa
• Reattività contro le specie: bovine, canine, hamster, kangaroo, human, monkey, rat, mouse
• Confezionamento: antibody small pack of 25 μL
• Concentrazione: ~1 mg/mL
• tecniche: immunoblotting: 1-2 μg/mL using using canine MDCK cells extract; immunofluorescence: 0.5-1 μg/mL using human epidermoid carcinoma A431 cells.
• Isotipo: IgG1
• N° accesso UniProt: P15311
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: mouse ... Ezr(22350)

Descrizione

Descrizione generale

Ezrin, also known as cytovillin, p81 or 80K, is a.member of the ERM proteins family composed of Ezrin, Radixin, and Moesin. These proteins are known as actin-binding proteins that link the cell membrane to the actin cytoskeleton, particularly in microvillus-bearing epithelial cells. Ezrin is present in microvilli, microspikes, and membrane ruffles of cells.
The ERM proteins family are involved in the functional expression of membrane proteins on the cell surface, integrate Rho guanosine 5′-triphosphatase (GTPase) signaling regulating cytoskeletal organization and act as protein kinase A (PKA)-anchoring proteins. Therefore, ERM proteins seem to play an important role in the membrane transport of electrolytes by ion channels and transporters.

Immunogeno

The carboxy-terminal part of recombinant human ezrin

Applicazioni

Monoclonal Anti-Ezrin recognizes an epitope located on the C-terminal region of Ezrin. Reactivity has been observed with human, mouse, hamster, monkey, bovine, canine, rat and rat-kangaroo origin. The antibody is recommended to use in various immunological techniques, including Immunoblotting (~80kDa), immunofluorescence, Immunohistochemistry and immunoprecipitation.

Stato fisico

Supplied as a solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide as a preservative.

Altre note

This product is for R&D use only, not for drug, household, or other uses.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1