S8647
Sulfacetamide sodium salt monohydrate
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Informazioni su questo articolo
Formula empirica (notazione di Hill):
C8H9N2NaO3S · H2O
Numero CAS:
Peso molecolare:
254.24
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
51102829
MDL number:
form
powder
color
white to off-white
solubility
H2O: soluble 50 mg/mL
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria, mycoplasma
mode of action
DNA synthesis | interferes, enzyme | inhibits
SMILES string
NC1=CC=C(S(N([Na])C(C)=O)(=O)=O)C=C1.O
InChI
1S/C8H10N2O3S.Na.H2O/c1-6(11)10-14(12,13)8-4-2-7(9)3-5-8;;/h2-5H,9H2,1H3,(H,10,11);;1H2/q;+1;/p-1
InChI key
IHCDKJZZFOUARO-UHFFFAOYSA-M
General description
Chemical structure: sulfonamide
Biochem/physiol Actions
Sulfacetamide is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfacetamide is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid[1]. It is active against Gram positive bacteria, Gram negative bacteria and Chlamydia. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.
Packaging
100G
Other Notes
Keep container tightly closed in a dry and well-ventilated place.Storage class (TRGS 510): Non Combustible Solids
Classe di stoccaggio
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Shmuel Graffi et al.
European journal of ophthalmology, 22(5), 834-835 (2012-01-24)
To report an unusual case of a patient with endogenous endophthalmitis caused by Actinomyces neuii. A 69-year-old woman in an immunosuppressed state and who had a previous history of periappendicular abscess presented with bilateral red painful eyes. The diagnosis was
Praveen N Naik et al.
Biopharmaceutics & drug disposition, 31(2-3), 120-128 (2010-01-15)
The binding of sulfacetamide sodium (SAS) to bovine serum albumin (BSA) was investigated by spectroscopic methods, namely fluorescence, FT-IR and UV-vis absorption spectral studies. The binding parameters were evaluated by a fluorescence quenching method. The thermodynamic parameters, DeltaH(0), DeltaS(0)and DeltaG(0)
A Parodi et al.
Annales de dermatologie et de venereologie, 138 Suppl 3, S211-S214 (2012-01-04)
A range of treatment options are available in rosacea, which include several topical (mainly metronidazole, azelaic acid, other antibiotics, sulfur, retinoids) and oral drugs (mainly tetracyclines, metronidazole, macrolides). In some cases, the first choice is a systemic therapy because patients
Numero articolo commerciale globale
| SKU | GTIN |
|---|---|
| S8647-100G | 04061836960971 |