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S8647

Sigma-Aldrich

Sulfacetamide sodium salt monohydrate

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About This Item

Formula empirica (notazione di Hill):
C8H9N2NaO3S · H2O
Numero CAS:
6209-17-2
Peso molecolare:
254.24
Numero MDL:
MFCD00149555
Codice UNSPSC:
51102829
ID PubChem:
24899806
NACRES:
NA.85

Stato

powder

Colore

white to off-white

Solubilità

H2O: soluble 50 mg/mL

Spettro attività antibiotica

Gram-negative bacteria
Gram-positive bacteria
mycoplasma

Modalità d’azione

DNA synthesis | interferes
enzyme | inhibits

Stringa SMILE

NC1=CC=C(S(N([Na])C(C)=O)(=O)=O)C=C1.O

InChI

1S/C8H10N2O3S.Na.H2O/c1-6(11)10-14(12,13)8-4-2-7(9)3-5-8;;/h2-5H,9H2,1H3,(H,10,11);;1H2/q;+1;/p-1
IHCDKJZZFOUARO-UHFFFAOYSA-M

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Descrizione generale

Chemical structure: sulfonamide

Azioni biochim/fisiol

Sulfacetamide is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfacetamide is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid[1]. It is active against Gram positive bacteria, Gram negative bacteria and Chlamydia. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.

Confezionamento

100G

Altre note

Keep container tightly closed in a dry and well-ventilated place.Storage class (TRGS 510): Non Combustible Solids

Codice della classe di stoccaggio

13 - Non Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
0000080723
088M4754V
107M4763V
116M4760V
066M4778V

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Bivash Mandal et al.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 13(4), 510-523 (2010-01-01)
Polymeric nanosuspension was prepared from an inert polymer resin (Eudragit® RL100) with the aim of improving the availability of sulfacetamide at the intraocular level to combat bacterial infections. Nanosuspensions were prepared by the solvent displacement method using acetone and Pluronic®
Demet Sensoy et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 72(3), 487-495 (2009-02-19)
The aim of this study was to prepare bioadhesive sulfacetamide sodium (SA) microspheres to increase their residence time on the ocular surface and to enhance their treatment efficacy on ocular keratitis. Microspheres were fabricated by spray drying method using mixture
Shmuel Graffi et al.
European journal of ophthalmology, 22(5), 834-835 (2012-01-24)
To report an unusual case of a patient with endogenous endophthalmitis caused by Actinomyces neuii. A 69-year-old woman in an immunosuppressed state and who had a previous history of periappendicular abscess presented with bilateral red painful eyes. The diagnosis was
Mark W Trumbore et al.
Journal of drugs in dermatology : JDD, 8(3), 299-304 (2009-03-11)
Acne rosacea is a chronic cutaneous disorder affecting as many as 14 million Americans. Papulopustular rosacea is the classic form of rosacea characterized by papules, pustules, and erythema. The skin barrier deficiency and vascular hyperactivity characteristic of papulopustular rosacea increase
Praveen N Naik et al.
Biopharmaceutics & drug disposition, 31(2-3), 120-128 (2010-01-15)
The binding of sulfacetamide sodium (SAS) to bovine serum albumin (BSA) was investigated by spectroscopic methods, namely fluorescence, FT-IR and UV-vis absorption spectral studies. The binding parameters were evaluated by a fluorescence quenching method. The thermodynamic parameters, DeltaH(0), DeltaS(0)and DeltaG(0)
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