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S8626

Sigma-Aldrich

Sulfadiazine

99.0-101.0%

Sinonimo/i:

4-Amino-N-(2-pyrimidinyl)benzenesulfonamide, N1-(Pyrimidin-2-yl)sulfanilamide

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About This Item

Formula empirica (notazione di Hill):
C10H10N4O2S
Numero CAS:
68-35-9
Peso molecolare:
250.28
Beilstein:
6733588
Numero CE:
200-685-8
Numero MDL:
MFCD00006065
Codice UNSPSC:
51283908
ID PubChem:
24899802
NACRES:
NA.85

Descrizione

Solubility - Practically insoluble in water, slightly soluble in acetone, very slightly soluble in ethanol (96 per cent). It dissolves in solutions of alkali hydroxides and in dilute mineral acids.

Saggio

99.0-101.0%

Forma fisica

powder or crystals

Colore

white to faint yellow, faint pink

Punto di fusione

253 °C (dec.) (lit.)

Solubilità

96% ethanol: very slightly soluble
acetone: slightly soluble
water: practically insoluble

Spettro attività antibiotica

Gram-negative bacteria
Gram-positive bacteria
mycoplasma

Modalità d’azione

DNA synthesis | interferes
enzyme | inhibits

Stringa SMILE

Nc1ccc(cc1)S(=O)(=O)Nc2ncccn2

InChI

1S/C10H10N4O2S/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10/h1-7H,11H2,(H,12,13,14)
SEEPANYCNGTZFQ-UHFFFAOYSA-N

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Categorie correlate

Descrizione generale

Chemical structure: sulfonamide

Applicazioni

Sulfadiazine is a short-acting sulfonamide that is commonly used with pyrimethamine to treat toxoplasmosis in patients with acquired immunodeficiency syndrome. It is also used to treat newborns with congenital infections. Sulfadiazine has been used to control acute infections when studying murine models of reactivated toxoplasmosis.

Azioni biochim/fisiol

Sulfadiazine is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfadiazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. It is active against Gram positive bacteria, Gram negative bacteria and Chlamydia. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.

Altre note

Keep container tightly closed in a dry and well-ventilated place.Storage class (TRGS 510): Non Combustible Solids

Avvertenze

Warning

Indicazioni di pericolo

H302,H361d,H411

Classi di pericolo

Acute Tox. 4 Oral - Aquatic Chronic 2 - Repr. 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Sulfadiazine Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1343

Sulfadiazine

Sulfapyridine ≥99.0%

Supelco

S6252

Sulfapyridine

Sulfadimethoxine 98.0-102.0%

Supelco

S7007

Sulfadimethoxine

Sulfamethoxazole

Supelco

S7507

Sulfamethoxazole

Sulfadiazine-(phenyl-13C6) VETRANAL®, analytical standard

Supelco

32518

Sulfadiazine-(phenyl-13C6)

Sulfameter

Sigma-Aldrich

S0383

Sulfameter

Romain Sonneville et al.
Neurology, 79(17), 1762-1766 (2012-10-12)
Cerebral toxoplasmosis remains a common neurologic complication in patients with AIDS. In this study, we aimed to characterize the prognosis of patients with HIV infection with severe forms of cerebral toxoplasmosis and to investigate the effects of adjunctive steroids on
Sven Jechalke et al.
Applied and environmental microbiology, 79(5), 1704-1711 (2013-01-15)
Spreading manure containing antibiotics in agriculture is assumed to stimulate the dissemination of antibiotic resistance in soil bacterial populations. Plant roots influencing the soil environment and its microflora by exudation of growth substrates might considerably increase this effect. In this
Ildiko R Dunay et al.
Antimicrobial agents and chemotherapy, 53(10), 4450-4456 (2009-07-29)
Immunocompromised patients are at risk of developing toxoplasmosis, and although chemotherapy is available, standard treatments are often complicated by severe side effects. Artemisinin is a new highly potent antimalarial drug that has activity against Toxoplasma gondii in vitro. However, artemisinin
Pascale Meneceur et al.
Antimicrobial agents and chemotherapy, 52(4), 1269-1277 (2008-01-24)
Sulfadiazine, pyrimethamine, and atovaquone are widely used for the treatment of severe toxoplasmosis. Their in vitro activities have been almost exclusively demonstrated on laboratory strains belonging to genotype I. We determined the in vitro activities of these drugs against 17
Tamim M Niazi et al.
International journal of radiation oncology, biology, physics, 84(3), e305-e310 (2012-06-02)
For patients with anal canal and advanced rectal cancer, chemoradiation therapy is a curative modality or an important adjunct to surgery. Nearly all patients treated with chemoradiation experience some degree of radiation-induced dermatitis (RID). Prevention and effective treatment of RID
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