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S6317

Sigma-Aldrich

L-Sulforaphane

≥95% (HPLC), oil

Sinonimo/i:

(R)-1-Isothiocyanato-4-(methylsulfinyl)butane, 4-Methylsulfinylbutyl isothiocyanate

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About This Item

Formula empirica (notazione di Hill):
C6H11NOS2
Numero CAS:
142825-10-3
Peso molecolare:
177.29
Numero MDL:
MFCD09039283
Codice UNSPSC:
12352200
ID PubChem:
24724618
NACRES:
NA.77

Saggio

≥95% (HPLC)

Forma fisica

oil

Attività ottica

[α]/D -70 to -90°, c = 1.0 in chloroform-d

Colore

light yellow

Solubilità

DMSO: >5 mg/mL

Temperatura di conservazione

−20°C

Stringa SMILE

CS(=O)CCCCN=C=S

InChI

1S/C6H11NOS2/c1-10(8)5-3-2-4-7-6-9/h2-5H2,1H3/t10-/m1/s1
SUVMJBTUFCVSAD-SNVBAGLBSA-N

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Applicazioni

L-Sulforaphane was used to study Nrf2-mediated signaling in mouse primary preadipocytes6 and murine macrophage RAW 264.7 cell line.7

Azioni biochim/fisiol

L-Sulforaphane is a potent, selective inducer of phase II detoxification enzymes with anticarcinogenic properties. Organosulfur compound found in cruciferous vegetables, including broccoli.
Sulforaphane is an anti-cancer, anti-microbial and anti-diabetic compound found in cruciferous vegetables.3,4 It induces the production of detoxifying enzymes such as quinone reductase and glutathione S-transferase that cause xenobiotic transformation. Sulforaphane also increases the transcription of tumor suppressor proteins and inhibits histone deacetylases. It modulates inflammatory responses by suppressing the LPS-mediated expression of iNOS, COX-2, IL-1β and TNF-α.3,5

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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ML385 ≥98% (HPLC)

Sigma-Aldrich

SML1833

ML385

Benzyl isothiocyanate 98%

Sigma-Aldrich

252492

Benzyl isothiocyanate

Phenethyl isothiocyanate 99%

Sigma-Aldrich

253731

Phenethyl isothiocyanate

Thioglucosidase from Sinapis alba (white mustard) seed ≥100 units/g solid

Sigma-Aldrich

T4528

Thioglucosidase from Sinapis alba (white mustard) seed

Allyl isothiocyanate 95%

Sigma-Aldrich

377430

Allyl isothiocyanate

Menadione European Pharmacopoeia (EP) Reference Standard

M0300000

Menadione

Valeria Capurro et al.
PloS one, 8(2), e56870-e56870 (2013-02-27)
Alzheimer's disease (AD) is characterized by progressive loss of cognitive function, dementia and altered behavior. Over 30 million people worldwide suffer from AD and available therapies are still palliative rather than curative. Recently, Memoquin (MQ), a quinone-bearing polyamine compound, has
Tiziana Latronico et al.
Inflammopharmacology, 29(2), 561-571 (2020-11-17)
Isothiocyanates (ITCs), present as glucosinolate precursors in cruciferous vegetables, have shown anti-inflammatory, antioxidant and anticarcinogenic activities. Here, we compared the effects of three different ITCs on ROS production and on the expression of matrix metalloproteinase (MMP)-2 and -9, which represent
Mohammed Ali Selo et al.
Frontiers in bioengineering and biotechnology, 8, 1030-1030 (2020-10-06)
Multidrug resistance-associated protein-1 (MRP1/ABCC1) is highly expressed in human lung tissues. Recent studies suggest that it significantly affects the pulmonary disposition of its substrates, both after pulmonary and systemic administration. To better understand the molecular mechanisms involved, we studied the
Pengfei Liu et al.
Redox biology, 38, 101766-101766 (2020-10-31)
Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible disease characterized by an increase in differentiation of fibroblasts to myofibroblasts and excessive accumulation of extracellular matrix in lung tissue. Pharmacological activation of NRF2 has proved to be a valuable antifibrotic
David Olagnier et al.
Nature communications, 9(1), 3506-3506 (2018-08-31)
The transcription factor Nrf2 is a critical regulator of inflammatory responses. If and how Nrf2 also affects cytosolic nucleic acid sensing is currently unknown. Here we identify Nrf2 as an important negative regulator of STING and suggest a link between
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