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R9157

Sigma-Aldrich

Ro 4-1284

≥98% (HPLC)

Sinonimo/i:

2-Hydroxy-2-ethyl-3-isobutyl-9,10-dimethoxy-1,2,3,4,5,6,7-hexahydrobenzo[a]chinolizine

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About This Item

Formula empirica (notazione di Hill):
C21H33NO3
Numero CAS:
303-75-3
Peso molecolare:
347.49
Numero MDL:
MFCD01663028
Codice UNSPSC:
12352200
ID PubChem:
329824045

Saggio

≥98% (HPLC)

Stato

solid

Solubilità

DMSO: 16 mg/mL

Ideatore

Roche

Temperatura di conservazione

2-8°C

Stringa SMILE

CCC1(O)CC2N(CCc3cc(OC)c(OC)cc23)CC1CC(C)C

InChI

1S/C21H33NO3/c1-6-21(23)12-18-17-11-20(25-5)19(24-4)10-15(17)7-8-22(18)13-16(21)9-14(2)3/h10-11,14,16,18,23H,6-9,12-13H2,1-5H3
TUNMGCULOKMBNJ-UHFFFAOYSA-N

Azioni biochim/fisiol

Ro 4-1284 is a reversible VMAT2 inhibitor.

Caratteristiche e vantaggi

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pittogrammi

Environment
GHS09

Avvertenze

Warning

Indicazioni di pericolo

H400

Consigli di prudenza

P273

Classi di pericolo

Aquatic Acute 1

Codice della classe di stoccaggio

13 - Non Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
089K4610

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D R Bull et al.
Neuroscience letters, 134(1), 41-44 (1991-12-16)
The present study has employed the technique of fast cyclic voltammetry to measure electrically-evoked dopamine release within the central amygdaloid complex in a rat brain slice. Local electrical stimulation caused the release of an electroactive substance which was identified, biochemically
G C Haralabopoulos et al.
Laboratory investigation; a journal of technical methods and pathology, 71(4), 575-582 (1994-10-01)
The formation of a basement membrane is the last step in the development of a new blood vessel. Matrigel, a laminin-rich reconstituted basement membrane matrix induces the differentiation of endothelial cells into capillary-like structures. The effect of inhibitors of basement
E Schömig et al.
Naunyn-Schmiedeberg's archives of pharmacology, 342(2), 160-170 (1990-08-01)
After loading of the incubated rat vas deferens with 0.2 mumol/l 3H-noradrenaline (followed by 100 min of wash-out with amine-free solution), the efflux of endogenous and exogenous compounds was determined by HPLC with electrochemical detection and by column chromatography with
G Karakiulakis et al.
Journal of cellular biochemistry, 52(1), 92-106 (1993-05-01)
Type IV collagen-degrading activity was expressed in homogenates of Lytechinus pictus embryos during embryogenesis. Activity was concentrated 1,600-fold by ammonium sulfate fractionation, ion exchange, and gel chromatography and could not be activated further upon trypsin or organomercurial treatment. This enzyme
G A Marks et al.
Brain research, 815(1), 21-28 (1999-02-12)
Ponto-geniculo-occipital (PGO) waves are spontaneously occurring field potentials recorded in the dorsal lateral geniculate nucleus (LGN) just prior to and during rapid eye movement (REM) sleep. Facilitated discharge rates of LGN neurons are associated with PGO waves. In kittens during
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