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R6527

Sigma-Aldrich

Reboxetine mesylate hydrate

>96% (HPLC), solid

Sinonimo/i:

(2R)-rel-2-[(R)-(2-Ethoxyphenoxy)phenylmethyl]morpholine, Edronax, Vestra

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5 MG
CHF 339.00
25 MG
CHF 1’280.00

CHF 339.00

Spedizione prevista il04 aprile 2025

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5 MG
CHF 339.00
25 MG
CHF 1’280.00

About This Item

Formula empirica (notazione di Hill):
C19H23NO3 · CH3SO3H · xH2O
Numero CAS:
98769-84-7
Peso molecolare:
409.50 (anhydrous basis)
Numero MDL:
MFCD11046031
Codice UNSPSC:
12352200
ID PubChem:
24724592
NACRES:
NA.77

CHF 339.00

Spedizione prevista il04 aprile 2025

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Livello qualitativo

100

Saggio

>96% (HPLC)

Stato

solid

Condizioni di stoccaggio

desiccated

Colore

white to tan

Solubilità

H2O: >5 mg/mL at ≤60 °C

Condizioni di spedizione

wet ice

Temperatura di conservazione

2-8°C

Stringa SMILE

O.CS(O)(=O)=O.CCOc1ccccc1O[C@@H]([C@H]2CNCCO2)c3ccccc3

InChI

1S/C19H23NO3.CH4O3S.H2O/c1-2-21-16-10-6-7-11-17(16)23-19(15-8-4-3-5-9-15)18-14-20-12-13-22-18;1-5(2,3)4;/h3-11,18-20H,2,12-14H2,1H3;1H3,(H,2,3,4);1H2/t18-,19-;;/m1../s1
SZPHEVAYLIVGRC-BAMQSBMESA-N

Applicazioni

Reboxetine mesylate hydrate has been used as a selective norepinephrine transport blocker:
  • to study its effects on the surge of dopamine in the cortex of mice brain[1]
  • to study its anti-immobility effects on the behavior of mice[2]
  • to analyze its effects on the probabilistic reversal learning task in rodents[3]

Azioni biochim/fisiol

Reboxetine mesylate hydrate is a selective noradrenaline uptake inhibitor.
Reboxetine exhibits anti-depressant activity.[1]

Caratteristiche e vantaggi

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
0000183815
0000183816
0000178219
0000178219
081M4620V

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Hagar Gelbard-Sagiv et al.
Current biology : CB, 28(14), 2239-2249 (2018-07-10)
An identical sensory stimulus may or may not be incorporated into perceptual experience, depending on the behavioral and cognitive state of the organism. What determines whether a sensory stimulus will be perceived? While different behavioral and cognitive states may share
Özgür Devrim Can et al.
European journal of pharmacology, 699(1-3), 250-257 (2012-10-27)
The present study was designed to investigate the putative effect of vitexin, a flavone C-glucoside present in some drugs, medicinal plants and nutraceuticals, on the central nervous system. Vitexin (10-30 mg/kg) did not show significant alterations in the behaviour of
Matthew P Wilkinson et al.
Brain and neuroscience advances, 4, 2398212820907177-2398212820907177 (2020-03-29)
Deficits in reward processing are a central feature of major depressive disorder with patients exhibiting decreased reward learning and altered feedback sensitivity in probabilistic reversal learning tasks. Methods to quantify probabilistic learning in both rodents and humans have been developed
Jeremy Koppel et al.
Journal of neurochemistry, 148(1), 127-135 (2018-09-22)
In Alzheimer's disease, the phosphorylation of tau is a critical event preceding the formation of neurofibrillary tangles. Previous work exploring the impact of a dopamine blocking antipsychotic on tau phosphorylation in a tau transgenic model suggested that extracellular dopamine may
Dennis K Miller et al.
The Journal of pharmacology and experimental therapeutics, 302(2), 687-695 (2002-07-20)
The present study determined whether repeated administration of the antidepressant and selective norepinephrine (NE) uptake inhibitor reboxetine resulted in an adaptive modification of the function of the NE transporters (NETs), serotonin (5-HT) transporters, or dopamine (DA) transporters. Because antidepressants may
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