V7264

Venlafaxine

≥98% (HPLC), serotonin-noradrenaline reuptake inhibitor, powder

• Sinonimo/i: (+/-)-1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol hydrochloride, Effexor
• Formula empirica (notazione di Hill): C₁₇H₂₇NO₂ · HCl
• Numero CAS: 99300-78-4
• Peso molecolare: 313.86
• UNSPSC Code: 12352200
• PubChem Substance ID: 329829062
• NACRES: NA.77
• MDL number: MFCD03658865
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated, protect from light

Proprietà

• Nome del prodotto: Venlafaxine, ≥98% (HPLC), powder
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated, protect from light
• color: white
• solubility: H₂O: >10 mg/mL
• originator: Wyeth
• SMILES string: Cl[H].COc1ccc(cc1)C(CN(C)C)C2(O)CCCCC2
• InChI: 1S/C17H27NO2.ClH/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14;/h7-10,16,19H,4-6,11-13H2,1-3H3;1H
• InChI key: QYRYFNHXARDNFZ-UHFFFAOYSA-N
• Gene Information: human ... SLC6A2(6530), SLC6A4(6532)

Descrizione

Biochem/physiol Actions

Venlafaxine is a dual serotonin-noradrenaline reuptake inhibitor that displays Ki values of 82 and 2480 nM respectively. It is a general class antidepressant.

Venlafaxine is an antidepressant. The mechanism of the antidepresant action of venlafaxine in humans is associated with its potentiation of neurotransmitter activity in the CNS. Venlafaxine is a potent inhibitor of neuronal serotonin and norepinephrine reuptake and weak inhibitor of dopamine reuptake. Venlafaxine has no significant activity for muscarinic, histaminergic, or α-1 adrenergic receptors in vitro. Venlafaxine does not possess MAO inhibitor activity.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informazioni sulla sicurezza

• pictograms: GHS09
• hcodes: H411
• pcodes: P273 - P391 - P501
• Hazard Classifications: Aquatic Chronic 2
• Classe di stoccaggio: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves