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R2530

Sigma-Aldrich

Ropinirole hydrochloride

powder, ≥98% (HPLC)

Sinonimo/i:

4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one hydrochloride, SKF 101468 hydrochloride

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CHF 85.70
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CHF 325.00

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25 MG
CHF 85.70
100 MG
CHF 325.00

About This Item

Formula empirica (notazione di Hill):
C16H24N2O · HCl
Numero CAS:
91374-20-8
Peso molecolare:
296.84
Numero MDL:
MFCD01754173
Codice UNSPSC:
12352200
ID PubChem:
329824018
NACRES:
NA.77

CHF 85.70

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Saggio

≥98% (HPLC)

Stato

powder

Condizioni di stoccaggio

desiccated

Colore

light yellow

Solubilità

H2O: >10 mg/mL

Ideatore

GlaxoSmithKline

Stringa SMILE

Cl.CCCN(CCC)CCc1cccc2NC(=O)Cc12

InChI

1S/C16H24N2O.ClH/c1-3-9-18(10-4-2)11-8-13-6-5-7-15-14(13)12-16(19)17-15;/h5-7H,3-4,8-12H2,1-2H3,(H,17,19);1H
XDXHAEQXIBQUEZ-UHFFFAOYSA-N

Informazioni sul gene

human ... DRD2(1813) , DRD3(1814) , DRD4(1815)

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Azioni biochim/fisiol

An agonist at the D2 and D3 dopamine receptor subtypes, binding with higher affinity to D3 than to D2 or D4. It has negligible effect on D1-receptors. It has medium in vitro affinity to opioid receptors. Ropinirole is said to have virtually no affinity to 5-HT1, 5-HT2, benzodiazepine, GABA, muscarinic, α1-, α2-, and β-adrenoreceptors. Used as antiparkinsonian drug.
Ropinirole hydrochloride is effectively used to treat early and late Parkinson′s disease.[1]
Selective D2 dopamine receptor agonist, antiparkinsonian

Caratteristiche e vantaggi

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pittogrammi

Exclamation markEnvironment
GHS07,GHS09

Avvertenze

Warning

Indicazioni di pericolo

H302,H400

Classi di pericolo

Acute Tox. 4 Oral - Aquatic Acute 1

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
0000219161
0000184635
0000187659
0000187658
125M4745V

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Sigma-Aldrich

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(−)-Quinpirole hydrochloride

Ropinirole hydrochloride European Pharmacopoeia (EP) Reference Standard

Y0001773

Ropinirole hydrochloride

Teniposide ≥97% (HPLC)

Sigma-Aldrich

SML0609

Teniposide

Francisco J Zagmutt et al.
The International journal of neuroscience, 122(7), 345-353 (2012-02-07)
The comparative safety profiles of monotherapeutic treatments for Parkinson's disease (PD) can provide valuable therapeutic information. The objective of this study was to perform an indirect comparison of Adverse Events (AEs) and Dropout Rates (DRs) among clinical trials of pramipexole
N Hattori et al.
Journal of clinical pharmacy and therapeutics, 37(5), 571-577 (2012-03-07)
Ropinirole hydrochloride, a dopamine receptor agonist with a non-ergot alkaloid structure, is highly selective for the dopamine D(2) /D(3) receptors. This study was conducted to evaluate the steady-state pharmacokinetics, safety and efficacy after repeated oral administration of prolonged-release tablets of
Dopamine agonist withdrawal syndrome in a patient with restless legs syndrome.
Benjamin J Dorfman et al.
Parkinsonism & related disorders, 19(2), 269-270 (2012-07-04)
T Nissen et al.
Scottish medical journal, 57(4), 217-220 (2012-09-25)
The expected duration of initial antiparkinson monotherapy before the need for supplementation is not clearly defined for routine practice. The aim of this study was to define the length of L-dopa (L-3, 4-dihydrophenylalanine) and dopamine agonist monotherapy. The duration of
Sébastien Duband et al.
Journal of forensic and legal medicine, 19(7), 422-425 (2012-08-28)
Ropinirole, a specific non-ergoline dopamine D2-receptor agonist, belongs to the drugs applied in treatment of Parkinson's disease (PD) and restless legs syndrome (RLS) and acts as a D2, D3, and D4 dopamine receptor agonist with highest affinity for D3. Therapeutic
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