P9297

Paromomycin sulfate salt

≥98% (TLC)

• Sinonimo/i: Aminosidine sulfate
• Formula empirica (notazione di Hill): C₂₃H₄₅N₅O₁₄ · xH₂SO₄
• Numero CAS: 1263-89-4
• Peso molecolare: 615.63 (free base basis)
• Beilstein: 5715182
• Codice UNSPSC: 51281663
• ID PubChem: 24278662
• NACRES: NA.85

Proprietà

• Livello qualitativo: 200
• Saggio: ≥98% (TLC)
• Forma fisica: powder
• Spettro attività antibiotica: Gram-negative bacteria; Gram-positive bacteria; parasites
• Modalità d’azione: protein synthesis | interferes
• Stringa SMILE: O[C@H]1[C@H](O)[C@@H](CO)O[C@H](O[C@@]2([H])[C@H](O[C@@]3([H])[C@H](O)[C@H](O[C@]4([H])[C@H](N)[C@@H](O)[C@H](O)[C@H](CN)O4)[C@@H](CO)O3)[C@@H](O)[C@H](N)C[C@@H]2N)[C@@H]1N.C
• InChI: 1S/C23H45N5O14.CH4/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;/h5-23,29-36H,1-4,24-28H2;1H4/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;/m1./s1; OYJABWUHUYVDMJ-UDXJMMFXSA-N

Descrizione

Descrizione generale

Chemical structure: aminoglycoside

Applicazioni

Paromomycin is a broad spectrum aminoglycoside antibiotic produced by Streptomyces rimosus var. paromomycinus. It has in vitro and in vivo activity similar to neomycin. It is effective against Gram-negative bacteria, Gram-positive bacteria, some protozoan species, and limited antihelminth.
It is used to study bacterial protein synthesis at the level of 16S ribosomal RNA and 30S ribosome assembly. Paromomycin is used to study cytosine-cytosine (CC) mismatch-containing RNA molecules and is used to inhibit Cryptosporidium infection of a human enterocyte cell line.

Azioni biochim/fisiol

Paromomycin inhibits the initiation and elongation steps of protein synthesis by binding to 16S ribosomal RNA. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced and leads to cell death.

Confezionamento

1g,5g,25g

Altre note

Keep container tightly closed in a dry and well-ventilated place.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable