Passa al contenuto
Merck
Tutte le immagini(1)

Documenti

P9246

Sigma-Aldrich

PB28 dihydrochloride

≥98% (HPLC), solid

Sinonimo/i:

1-Cyclohexyl-4-(3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)-n-propyl)piperazine dihydrochloride

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Tutte le immagini(1)

About This Item

Formula condensata:
C24H40Cl2N2O
Numero CAS:
172906-90-0
Peso molecolare:
443.49
Numero MDL:
MFCD06798349
Codice UNSPSC:
12352200
ID PubChem:
329820345
NACRES:
NA.77

Saggio

≥98% (HPLC)

Forma fisica

solid

Condizioni di stoccaggio

desiccated

Colore

white

Solubilità

H2O: ~10 mg/mL at 60 °C

Stringa SMILE

Cl[H].Cl[H].COc1cccc2C(CCCN3CCN(CC3)C4CCCCC4)CCCc12

InChI

1S/C24H38N2O.2ClH/c1-27-24-14-6-12-22-20(8-5-13-23(22)24)9-7-15-25-16-18-26(19-17-25)21-10-3-2-4-11-21;;/h6,12,14,20-21H,2-5,7-11,13,15-19H2,1H3;2*1H
DSRBJOQIBXACIV-UHFFFAOYSA-N

Applicazioni

PB28 dihydrochloride has been used to test its inhibitory effect on potassium voltage-gated channel, shab-related subfamily, member 1, Kv2.1.

Azioni biochim/fisiol

PB28, a cyclohexylpiperazine derivative, is a sigma 1 (σ1)-R antagonist. It elicits anti-tumor activity in breast, ovarian and colorectal cancer cell lines.
Selective σ2 opioid receptor ligand; putative σ2 agonist

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H315,H319,H335

Classi di pericolo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

Nicola Antonio Colabufo et al.
Cancer letters, 237(1), 83-88 (2005-07-12)
Sigma2 (sigma2) receptor proteins are overexpressed in several tissues and tumour cell lines. Although the biomolecular mechanism of this overexpression must be elucidated, sigma2 receptor was considered a potential biomarker for monitoring solid tumour proliferation. In this study, we verified
Xinying Liu et al.
Oncotarget, 8(35), 59345-59358 (2017-09-25)
The sigma-1 receptor (σ1-R) and sigma-2 receptor (σ2-R) are potential drug targets for treatment of cancer, pain, depression, retinal degeneration and other neuronal diseases. Previous reports show that sigma-1 receptor modulates the activities of multiple channels. We are interested in
Nicola A Colabufo et al.
Naunyn-Schmiedeberg's archives of pharmacology, 368(2), 106-112 (2003-07-25)
We demonstrated the presence of sigma(2) receptors in the guinea-pig ileum by saturation analysis and extended our investigation to guinea-pig bladder and rat bladder. In functional assays of the isolated tissues in organ baths, sigma(2) receptor ligands inhibited electrically evoked
Evangelia Sereti et al.
Biomedicines, 9(1) (2021-01-21)
Sigma (σ) receptors have attracted great interest since they are implicated in various cellular functions and biological processes and diseases, including various types of cancer. The receptor family consists of two subtypes: sigma-1 (σ1) and sigma-2 (σ2). Both σ receptor

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.