5.08159

Salvinorin A

• Sinonimo/i: Salvinorin A, κ-opioid Receptor Agonist, Salvinorin A, Divinorin A
• Formula empirica (notazione di Hill): C₂₃H₂₈O₈
• Numero CAS: 83729-01-5
• Peso molecolare: 432.46
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD05664742
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: OK to freeze, protect from light

Proprietà

• assay: ≥98% (HPLC)
• Quality Segment: 100
• form: solid
• potency: 4.3 nM K_i
• manufacturer/tradename: Calbiochem^®
• drug control: Pszichotróp anyag / Psychotropic Substance (Hungary), 78/2022. (XII. 28.) BM rendelet
• storage condition: OK to freeze, protect from light
• color: white
• solubility: ethanol: 10 mM, DMSO: 50 mM
• storage temp.: −70°C
• SMILES string: [o]1cc(cc1)[C@H]2OC(=O)[C@H]3[C@@]([C@@H]4[C@]([C@@H](C[C@@H](C4=O)OC(=O)C)C(=O)OC)(CC3)C)(C2)C
• InChI: 1S/C23H28O8/c1-12(24)30-16-9-15(20(26)28-4)22(2)7-5-14-21(27)31-17(13-6-8-29-11-13)10-23(14,3)19(22)18(16)25/h6,8,11,14-17,19H,5,7,9-10H2,1-4H3/t14-,15-,16-,17-,19-,22-,23-/m0/s1
• InChI key: OBSYBRPAKCASQB-AGQYDFLVSA-N

Descrizione

General description

A highly potent and selective non-alkaloid positive allosteric modulator of Κ-opioid receptors (K_i = 4.3 nM and 16 nM for native and cloned κ-opioid receptors, respectively). Also acts as a D2DR partial agonist (K_i = 5-10 nM). Used in studies of addition.

Biochem/physiol Actions

Primary Target
k opioid receptor

Other Notes

Roth, B. et al., 2002. PNAS.99, 11934.
Valdés III., j., et al., 1984. J. Organic Chem.49, 4716.
Ortega, A., et al., 1982. J. of Chem. Society, Perkins Transactions I. 2505.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Informazioni sulla sicurezza

• Classe di stoccaggio: 11 - Combustible Solids
• wgk: WGK 3