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P9053

Sigma-Aldrich

Pyridine-2-aldoxime methochloride

Sinonimo/i:

2-PAM chloride, Pralidoxime chloride

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5 G
CHF 93.80
25 G
CHF 342.00

CHF 93.80

Spedizione prevista il25 marzo 2025

Tutte le immagini(3)

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Cambia visualizzazione
5 G
CHF 93.80
25 G
CHF 342.00

About This Item

Formula empirica (notazione di Hill):
C7H9N2O · Cl
Numero CAS:
51-15-0
Peso molecolare:
172.61
Numero CE:
200-080-9
Numero MDL:
MFCD00011981
Codice UNSPSC:
12352202
ID PubChem:
24899005
NACRES:
NA.77

CHF 93.80

Spedizione prevista il25 marzo 2025

Origine biologica

synthetic (organic)

Livello qualitativo

100

Stato

solid

Punto di fusione

230 °C (lit.)

Solubilità

water: 50 mg/mL, clear, colorless to faintly yellow

Stringa SMILE

[Cl-].C[n+]1ccccc1\C=N\O

InChI

1S/C7H8N2O.ClH/c1-9-5-3-2-4-7(9)6-8-10;/h2-6H,1H3;1H
HIGSLXSBYYMVKI-UHFFFAOYSA-N

Informazioni sul gene

human ... ACHE(43)

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Azioni biochim/fisiol

The prototypical reactivator of acetylcholinesterase that has been inactivated by organophosphorus insecticides or nerve agents. It is now known that no reactivator is effective against a broad spectrum of organophosphorus agents.[1]

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302 + H312 + H332

Classi di pericolo

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
WXBD8973V
MKCS1400
MKCM1413
MKCG3184
MKCC6716

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Diisopropylfluorophosphate

Sigma-Aldrich

D0879

Diisopropylfluorophosphate

2-Pyridinecarboxaldehyde 99%

Sigma-Aldrich

P62003

2-Pyridinecarboxaldehyde

Acetylthiocholine iodide ≥98% (TLC), powder or crystals

Sigma-Aldrich

A5751

Acetylthiocholine iodide

Dimetil solfossido Hybri-Max™, sterile-filtered, BioReagent, suitable for hybridoma, ≥99.7%

Sigma-Aldrich

D2650

Dimetil solfossido

Chennamaneni Srinivas Rao et al.
Bioorganic & medicinal chemistry letters, 16(8), 2134-2138 (2006-02-17)
In continuation of our investigations of unsymmetrical bisquaternary monooximes, we synthesized four new series of compounds bridged by hexyl, heptyl, octyl and nonyl groups. All eight monooximes viz., dibromides of 1-(4-hydroxyiminomethylpyridinium)6-(3/4-carbamoylpyridinium)hexane, 1-(4-hydroxyiminomethylpyridinium)-7-(3/4-carbamoylpyridinium)heptane, 1-(4-hydroxyiminomethylpyridinium)-8-(3/4-carbamoylpyridinium)octane, 1-(4-hydroxyiminomethylpyridinium)-9-(3/4-carbamoylpyridinium)nonane as well as the corresponding bis-oximes
Kamil Musilek et al.
Bioorganic & medicinal chemistry, 16(17), 8218-8223 (2008-08-05)
Acetylcholinesterase reactivators are crucial antidotes for the treatment of organophosphate intoxication. Eighteen monoquaternary reactivators of acetylcholinesterase with modified side chain were developed in an effort to extend the properties of pralidoxime. The known reactivators (pralidoxime, HI-6, obidoxime, trimedoxime, methoxime) and
F Worek et al.
Archives of toxicology, 72(4), 237-243 (1998-05-20)
The treatment of poisoning by highly toxic organophosphorus compounds (nerve agents) is unsatisfactory. Until now, the efficacy of new potential antidotes has primarily been evaluated in animals. However, the extrapolation of these results to humans is hampered by species differences.
Kamil Musilek et al.
Bioorganic & medicinal chemistry letters, 17(11), 3172-3176 (2007-03-27)
Six novel AChE reactivators with a (Z)-but-2-ene linker were synthesized using the known synthetic pathways. Their ability to reactivate AChE, which had been previously inhibited by nerve agent tabun or pesticide paraoxon, was tested in vitro and compared to pralidoxime
Jarosław Kalisiak et al.
Journal of medicinal chemistry, 55(1), 465-474 (2011-12-31)
A new class of amidine-oxime reactivators of organophosphate (OP)-inhibited cholinesterases (ChE) was synthesized and tested in vitro and in vivo. Compared with 2-PAM, the most promising cyclic amidine-oxime (i.e., 12e) showed comparable or greater reactivation of OP-inactivated AChE and OP-inactivated
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