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P7936

Sigma-Aldrich

Phosphocreatine disodium salt hydrate

≥97%

Sinonimo/i:

Creatine phosphate disodium salt, N-(Imino[phosphonoamino]methyl)-N-methylglycine

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10 MG
CHF 44.50
1 G
CHF 117.00
5 G
CHF 266.00
25 G
CHF 809.00

CHF 44.50

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10 MG
CHF 44.50
1 G
CHF 117.00
5 G
CHF 266.00
25 G
CHF 809.00

About This Item

Formula condensata:
C4H8N3O5PNa2 · x H2O
Numero CAS:
19333-65-4
Peso molecolare:
255.08 (anhydrous basis)
Numero CE:
213-074-6
Numero MDL:
MFCD00150191
Codice UNSPSC:
12352204
ID PubChem:
24898895
NACRES:
NA.32

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Nome del prodotto

Phosphocreatine disodium salt hydrate, ≥97%

Livello qualitativo

200

Saggio

≥97%

Stato

powder

Impurezze

≤0.02% free creatine

Colore

white

Solubilità

water: 50 mg/mL, clear, colorless

Temperatura di conservazione

−20°C

Stringa SMILE

O.[Na+].[Na+].CN(CC(O)=O)C(=N)NP([O-])([O-])=O

InChI

1S/C4H10N3O5P.2Na.H2O/c1-7(2-3(8)9)4(5)6-13(10,11)12;;;/h2H2,1H3,(H,8,9)(H4,5,6,10,11,12);;;1H2/q;2*+1;/p-2
KZVYPOKBYRXZKS-UHFFFAOYSA-L

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Applicazioni

Phosphocreatine disodium salt hydrate has been used:
  • as a component: of Xenopus buffer (XB) buffer to remove the membrane-bound proteins[1]
  • of M5+ buffer to perform polarized total internal reflection fluorescence (polTIRF) experiments [2]
  • of ATP regenerating system for 7-nitro-2-1,3-benzoxadiazol-4-yl phospholipid(NBD-PL) translocation assay[3]

Azioni biochim/fisiol

Phosphocreatine disodium salt hydrate is useful to study nasopharyngeal carcinoma cells and induced temporary cardiac arrest. It also evaluate the effects of adenosine A(2A) receptor modulation in the nucleus accumbens on cocaine seeking in rats.
Phosphocreatine is widely known for its quickest form of regeneration using enzyme creatine kinase. It functions as a temporal energy buffer. Phosphocreatine is present in muscle tissues and plays a major role in maintaining energy homeostasis in muscle cells.[4]
Phosphocreatine, a high-energy phosphate reservoir in vertebrate and some invertebrate muscles, provides phosphate for ADP-ATP conversion.

Nota sulla preparazione

Prepared enzymatically

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
0000427472
0000427466
0000427477
0000427466
0000427477

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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

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Lucas Guimarães-Ferreira
Einstein (Sao Paulo, Brazil), 12(1), 126-131 (2014-04-15)
Adenosine triphosphate is the present energy currency in the body, and is used in various cellular and indispensable processes for the maintenance of cell homeostasis. The regeneration mechanisms of adenosine triphosphate, from the product of its hydrolysis - adenosine diphosphate
Protective effects of a magnesium magnetic isotope (Mg(25) )-exchanging nanoparticle ((25) MgPMC(16) ) on mitochondrial functional disorders in esmolol-induced cardiac arrest in rats
Adeli, S., et al.
Auton. Autocoid Pharmacol., 32, 1-7 (2012)
Casey E O'Neill et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 37(5), 1245-1256 (2011-12-16)
Repeated cocaine administration enhances dopamine D(2) receptor sensitivity in the mesolimbic dopamine system, which contributes to drug relapse. Adenosine A(2A) receptors are colocalized with D(2) receptors on nucleus accumbens (NAc) medium spiny neurons where they antagonize D(2) receptor activity. Thus
Cyril Bernis et al.
Methods in cell biology, 122, 165-191 (2014-05-27)
The large and complex eukaryotic nucleus is the arbiter of DNA replication, RNA transcription, splicing, and ribosome assembly. With the advent of in vitro nuclear reconstitution extracts derived from Xenopus eggs in the 1980s, it became possible to assemble multiple
John F Beausang et al.
Biophysical journal, 104(6), 1263-1273 (2013-03-27)
Myosin V is biomolecular motor with two actin-binding domains (heads) that take multiple steps along actin by a hand-over-hand mechanism. We used high-speed polarized total internal reflection fluorescence (polTIRF) microscopy to study the structural dynamics of single myosin V molecules
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Questions

1–3 of 3 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. Va bene come Fosfocreatina?

    1 answer

    1. The sodium form of phosphocreatine, in equimolar quantities, is comparable to the free form in biological activity. The sodium form demonstrates a higher solubility rate in water. Certain applications may require a specific form, which would have to be determined by the end user.

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