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P6273

Sigma-Aldrich

2-Propylpentanoic acid

Sinonimo/i:

Valproic acid

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About This Item

Formula condensata:
(CH3CH2CH2)2CHCO2H
Numero CAS:
99-66-1
Peso molecolare:
144.21
Numero CE:
202-777-3
Numero MDL:
MFCD00002672
Codice UNSPSC:
12352211
ID PubChem:
24898751
NACRES:
NA.25

Indice di rifrazione

n20/D 1.425 (lit.)

P. eboll.

220 °C (lit.)

Solubilità

H2O: slightly soluble
alcohol: soluble

Densità

0.9 g/mL at 25 °C (lit.)

Tipo di lipide

saturated FAs

Stringa SMILE

CCCC(C(O)=O)CCC

InChI

1S/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)
NIJJYAXOARWZEE-UHFFFAOYSA-N

Informazioni sul gene

human ... ALDH5A1(7915) , CYP1A2(1544)
mouse ... Hdac1(433759)
rat ... Slc6a1(79212)

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Applicazioni

2-Propylpentanoic acid has been used as a supplement in mouse embryonic fibroblast - conditioned medium (MEF-CM) to feed the cells.

Azioni biochim/fisiol

2-Propylpentanoic acid is a short-chain fatty acid and potentially inhibits histone deacetylase action. It is known to promote tumor cell toxicity and increase susceptibility to radiation. 2-Propylpentanoic acid elevates the levels of γ-aminobutyric acid in the brain. Reduced central nervous system action is observed in overdosage of 2-propylpentanoic acid. It enhance the inhibitory action of γ-aminobutyric acid (GABA) by blocking voltage-dependent sodium channel.
Anticonvulsant that also has efficacy as a mood stabilizer in bipolar disorder

Avvertenze

Danger

Indicazioni di pericolo

H302,H315,H318,H360FD

Classi di pericolo

Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 1A - Skin Irrit. 2

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

231.8 °F - closed cup

Punto d’infiammabilità (°C)

111 °C - closed cup

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Certificati d'analisi (COA)

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Supelco

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Efficient generation of nonhuman primate induced pluripotent stem cells
Zhong B, et al.
Stem Cells and Development, 20(5), 795-807 (2010)
3-Heptanone as a potential new marker for valproic acid therapy
Erhart S, et al.
Journal of Breath Research, 3(1), 016004-016004 (2009)
Histone deacetylase inhibitor, 2-propylpentanoic acid, increases the chemosensitivity and radiosensitivity of human glioma cell linesin vitro
Cuijie S, et al.
Chinese Medical Journal (English Edition), 125(24), 4338-4343 (2012)
Xi Chen et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(21), 9202-9213 (2013-05-24)
Progranulin (PGRN) is a secreted glycoprotein expressed in neurons and glia that is implicated in neuronal survival on the basis that mutations in the GRN gene causing haploinsufficiency result in a familial form of frontotemporal dementia (FTD). Recently, a direct
P C Ho et al.
The pharmacogenomics journal, 3(6), 335-342 (2003-11-05)
The present study investigated the effect of cytochrome P450 2C9 (CYP2C9) genetic polymorphism on the biotransformation of valproic acid (VPA) to its hepatotoxic metabolite, 4-ene-VPA, and compared that to the formation of the inactive 4-OH-VPA and 5-OH-VPA. cDNA-expressed CYP2C9(*)2 and
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