P5515

Prostaglandin E₁

≥98% (HPLC), powder, vasodilator 

• Sinonimo/i: (11α,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-enoic acid, Alprostadil, PGE₁
• Formula empirica (notazione di Hill): C₂₀H₃₄O₅
• Numero CAS: 745-65-3
• Peso molecolare: 354.48
• Beilstein: 5294062
• Numero CE: 212-017-2
• Numero MDL: MFCD00077860
• Codice UNSPSC: 12352211
• eCl@ss: 42020658
• ID PubChem: 57654538
• NACRES: NA.77

Proprietà

• product name: Prostaglandin E₁, ≥98% (HPLC), synthetic
• Origine biologica: synthetic
• Saggio: ≥98% (HPLC)
• Forma fisica: (powder to crystals)
• Solubilità: ethanol: 5 mg/mL
• Temperatura di conservazione: −20°C
• Stringa SMILE: O=C1[C@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@H](CCCCC)O)[C@H](O)C1
• InChI: 1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,19+/m0/s1; GMVPRGQOIOIIMI-DWKJAMRDSA-N
• Informazioni sul gene: human ... PTGER1(5731) , PTGER2(5732) , PTGIR(5739) ; mouse ... Ptger1(19216) , Ptger2(19217) , Ptger3(19218) , Ptger4(19219)

Descrizione

Applicazioni

Prostaglandin E1 has been used:

• as a platelet inhibitor to analyse its effect on autophagy
• in platelet adhesion assay
• to investigate its effect on cAMP production in thyroid glands of normal and growth-retarded mouse in vitro.

Azioni biochim/fisiol

Prostaglandin E1 (PGE1) is a hormone synthesized from dihomo-γ-linolenic acid (DGLA) by the action of enzyme prostaglandin synthase. It is a vasodilator and activates adenylate cyclase. It is majorly present in human semen and is a potent platelet aggregation inhibitor. PGE1 infusions is effective in treating limb ischemia and peripheral vascular disease. It is unstable and is hydrolyzed to PGA1 in the lungs. Nanoparticle encapsulation of PGE1 is essential for its delivery at the vascular injury site. It elicits vasodilator effects on the retinal artery and vein in central retinal artery occlusion (CRAO). PGE1 and its synthetic analog misoprostol interact with E-prostanoid receptor 4 (EP4) and elicits protection in chronic myelogenous leukemia (CML).

Informazioni sulla sicurezza

• Pittogrammi: GHS06
• Avvertenze: Danger
• Indicazioni di pericolo: H301
• Consigli di prudenza: P301 + P310 + P330
• Classi di pericolo: Acute Tox. 3 Oral
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Faceshields, Gloves