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P204

Sigma-Aldrich

Phenylbenzene ω-phosphono-α-amino acid

solid

Sinonimo/i:

3-[2′-Phosphonomethyl[1,1′-biphenyl]-3-yl]alanine, PMBA

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About This Item

Formula empirica (notazione di Hill):
C16H18NO5P
Peso molecolare:
335.29
Numero MDL:
MFCD00467903
Codice UNSPSC:
12352200
ID PubChem:
24278002

Forma fisica

solid

Colore

white

Solubilità

H2O: 0.15 mg/mL
DMSO: 0.2 mg/mL
0.1 M NaOH: >10 mg/mL

Stringa SMILE

N[C@@H](Cc1cccc(c1)-c2ccccc2CP(O)(O)=O)C(O)=O

InChI

1S/C16H18NO5P/c17-15(16(18)19)9-11-4-3-6-12(8-11)14-7-2-1-5-13(14)10-23(20,21)22/h1-8,15H,9-10,17H2,(H,18,19)(H2,20,21,22)/t15-/m0/s1
NCEGJIHRQBRVJQ-HNNXBMFYSA-N

Informazioni sul gene

human ... GRIN1(2902)

Azioni biochim/fisiol

Selective strychnine-sensitive glycine receptor antagonist.

Note legali

Made and sold under license from Nippon Chemiphar.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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K Watanabe et al.
Soft matter, 14(17), 3372-3377 (2018-04-06)
An external electric AC field with a field strength ranging from 10 V mm-1 to 30 V mm-1 and a frequency ranging from 0.1 kHz to 1 MHz was applied to suspensions of gold nanoparticles (Au NPs) to control their
Akihisa Otaka et al.
Journal of biomedical materials research. Part A, 108(10), 2090-2099 (2020-04-24)
Current chemotherapy methods have limited effectiveness in eliminating bone metastasis, which leads to a poor prognosis associated with severe bone disorders. To provide regional chemotherapy for this metastatic tumor, a bone-targeting drug carrier was produced by introducing the osteotropic bisphosphonate
Kanako Watanabe et al.
Journal of colloid and interface science, 566, 202-210 (2020-02-02)
Assembly of plasmonic nanoparticle clusters having hotspots in a specific space is an effective way to efficiently utilize their plasmonic properties. In the assembly, however, bulk-like aggregates of the nanoparticles are readily formed by strong van der Waals forces, inducing
T Saitoh et al.
British journal of pharmacology, 113(1), 165-170 (1994-09-01)
1. 3-[2'-Phosphonomethyl[1,1'-biphenyl]-3-yl]alanine (PMBA) is a novel glycine antagonist at strychnine-sensitive receptors. The chemical structure of PMBA, possessing both a glycine moiety and a phosphono group, is quite different from that of strychnine. 2. In the spinal motoneurone of newborn rats
Shahin Aghamiri et al.
IET nanobiotechnology, 13(8), 808-815 (2019-10-19)
Breast cancer is the second cause of death in the world. Ionising radiation is a potent mutagen that can cause DNA damage, chromosomes breakage, and cell death. In the present study, radiotherapy and nanoparticle-antibodies (ABs) have been combined to enhance
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