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P118

Sigma-Aldrich

Phaclofen

solid

Sinonimo/i:

3-Amino-2-(4-chlorophenyl)propanephosphonic acid

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CHF 135.00
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CHF 545.00
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CHF 1’840.00

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5 MG
CHF 135.00
25 MG
CHF 545.00
100 MG
CHF 1’840.00

About This Item

Formula empirica (notazione di Hill):
C9H13ClNO3P
Numero CAS:
114012-12-3
Peso molecolare:
249.63
Numero MDL:
MFCD00069328
Codice UNSPSC:
12352200
ID PubChem:
24278189
NACRES:
NA.32

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Stato

solid

Impurezze

≥97% (NMR)

Colore

white

Solubilità

0.1 M HCl: 13.3 mg/mL
methanol: 19.3 mg/mL
DMSO: insoluble

Stringa SMILE

NCC(CP(O)(O)=O)c1ccc(Cl)cc1

InChI

1S/C9H13ClNO3P/c10-9-3-1-7(2-4-9)8(5-11)6-15(12,13)14/h1-4,8H,5-6,11H2,(H2,12,13,14)
VSGNGLJPOGUDON-UHFFFAOYSA-N

Informazioni sul gene

human ... GABBR1(2550) , GABBR2(9568)

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Descrizione generale

Phaclofen is a phosphonic acid derivative of baclofen.[1]

Applicazioni

Phaclofen has been used to block GABAB receptor.[2]

Azioni biochim/fisiol

Phaclofen plays a vital role in identifying the physiological importance of central and peripheral bicuculline-insensitive receptors with which GABA and (−) baclofen interact.[1] Phaclofen acts as a GABAB receptor antagonist. Phaclofen has an ability to reversibly block the late, bicuculline resistant, K+ dependent inhibitory postsynaptic potential (IPSP) logged in projection cells of the cat and rat dorsal lateral geniculate nucleus and in rat hippocampal CA1 pyramidal neurons.[3]

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H315,H319,H335

Classi di pericolo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
042M4605V
066K4603
084H39003
084H39002
084H39001

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Sigma-Aldrich

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P Dutar et al.
Nature, 332(6160), 156-158 (1988-03-10)
The role of GABA in synaptic transmission in the mammalian central nervous system is more firmly established than for any other neurotransmitter. With virtually every neuron studied, the synaptic action of GABA is mediated by bicuculline-sensitive GABAA receptors which selectively
Effat Ramshini et al.
International journal of preventive medicine, 4(2), 158-164 (2013-04-02)
There is only little information about the effects of GABA receptors agonist and antagonist on morphine self-administration. Present study was designed to assess role of GABAB receptors in the regulation of morphine-reinforced self-administration. THIS STUDY WAS PERFORMED IN FOUR GROUPS
Kazuo Kunisawa et al.
European journal of pharmacology, 796, 122-130 (2016-12-13)
GABA mediated neuronal system regulates hippocampus-dependent memory and stress responses by controlling plasticity and neuronal excitability. Here, we demonstrate that betaine ameliorates water-immersion restraint stress (WIRS)-induced memory impairments. This improvement was inhibited by a betaine/GABA transporter-1 (GABA transporter-2: GAT2) inhibitor
The GABAB antagonist phaclofen inhibits the late K+-dependent IPSP in cat and rat thalamic and hippocampal neurones
Soltesz I, et al.
Brain Research, 448(2), 351-354 (1988)
Christof Geigerseder et al.
Reproductive biology and endocrinology : RB&E, 2, 13-13 (2004-03-26)
The neurotransmitter gamma-aminobutyric acid (GABA) and subtypes of GABA receptors were recently identified in adult testes. Since adult Leydig cells possess both the GABA biosynthetic enzyme glutamate decarboxylase (GAD), as well as GABA(A) and GABA(B) receptors, it is possible that
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