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N2162

Sigma-Aldrich

NH125

≥98% (HPLC), solid

Sinonimo/i:

1-Benzyl-3-cetyl-2-methylimidazolium iodide

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5 MG
CHF 333.00

CHF 333.00

Spedizione prevista il17 aprile 2025

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5 MG
CHF 333.00

About This Item

Formula empirica (notazione di Hill):
C27H45IN2
Numero CAS:
278603-08-0
Peso molecolare:
524.56
Numero MDL:
MFCD07370143
Codice UNSPSC:
12352200
ID PubChem:
329818598
NACRES:
NA.77

CHF 333.00

Spedizione prevista il17 aprile 2025

Livello qualitativo

100

Saggio

≥98% (HPLC)

Stato

solid

Colore

white to off-white

Punto di fusione

88.2-94.9 °C

Solubilità

DMSO: >20 mg/mL

Temperatura di conservazione

−20°C

Stringa SMILE

[I-].CCCCCCCCCCCCCCCC[n+]1ccn(Cc2ccccc2)c1C

InChI

1S/C27H45N2.HI/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-19-22-28-23-24-29(26(28)2)25-27-20-17-16-18-21-27;/h16-18,20-21,23-24H,3-15,19,22,25H2,1-2H3;1H/q+1;/p-1
RVWOHCBHAGBLLT-UHFFFAOYSA-M

Azioni biochim/fisiol

NH125 exhibits anti-proliferation activity against many cancer cells. It also exhibits antibacterial effects by inhibiting bacterial histidine protein kinase.[1]
NH125 is a novel plant histidine kinase inhibitor and selective mammalian eurkaryotic elongation factor-2 kinase (eEF-2K).

Confezionamento

Packaged under nitrogen.

Risultati analitici

IC50 = 60 nM for eEF-2 kinase vs protein kinase C (IC50= 7.5 μM), protein kinase A (IC50= 80 μM), and calmodulin-dependent kinase II IC50 > 100 μM).

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
0000176287
0000176287
0000056804
0000053795
048K4615

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Tomoko Kodama et al.
The Journal of veterinary medical science, 81(1), 35-41 (2018-11-16)
Eukaryotic elongation factor 2 (eEF2) kinase (eEF2K) inhibits protein translation through the phosphorylation of its specific substrate, eEF2. We previously demonstrated that eEF2K expression increases in superior mesenteric artery from spontaneously hypertensive rats (SHR) and that eEF2K mediates development of
Chih-Hua Chang et al.
Neuropharmacology, 143, 95-105 (2018-09-24)
When faced with stressful conditions, people with a tendency toward impulsive aggression may suddenly hurt others. We have previously shown that the blockade of NMDA receptors (NMDARs) within the ventral hippocampus (VH) produces anti-aggressive effects. However, little is known about
Tao Ma et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(36), 12230-12238 (2014-09-05)
The AMP-activated protein kinase (AMPK) is a Ser/Thr kinase that is activated in response to low-energy states to coordinate multiple signaling pathways to maintain cellular energy homeostasis. Dysregulation of AMPK signaling has been observed in Alzheimer's disease (AD), which is
Yuan-Yuan Zhao et al.
Drug design, development and therapy, 12, 2655-2663 (2018-09-15)
Our previous research showed that AKT inactivation via small molecule inhibitors did not induce significant apoptosis, but rather markedly increased autophagy in nasopharyngeal carcinoma (NPC). The purpose of the current study was to determine whether autophagy inhibition can enhance the
Zehan Chen et al.
The Journal of biological chemistry, 286(51), 43951-43958 (2011-10-25)
Eukaryotic elongation factor-2 kinase (eEF2K) relays growth and stress signals to protein synthesis through phosphorylation and inactivation of eukaryotic elongation factor 2 (eEF2). 1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) is a widely accepted inhibitor of mammalian eEF2K and an efficacious anti-proliferation agent against
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