This product is stored at -20°C and is not assigned an expiration or recommended retest date. Products with no expiration date or recommended retest date should be routinely inspected by customers to ensure they perform as expected. These products are also subject to a one-year warranty from the date of shipment. For more information, please access the Product Dating Information document under ADDITIONAL USEFUL DOCUMENTS ABOUT OUR PRODUCTS at the bottom of the Quality Services page with this link: https://www.sigmaaldrich.com/US/en/life-science/quality-and-regulatory-management/quality-services.
M7571
MK-571 sodium salt hydrate
MK-571 sodium salt hydrate
≥95% (HPLC), powder, leukotriene D4 antagonist
Sinonimo/i:
5-(3-(2-(7-Chloroquinolin-2-yl)ethenyl)phenyl)-8-dimethylcarbamyl-4,6-dithiaoctanoic acid sodium salt hydrate, L-660711
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5 MG
CHF 216.00
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CHF 561.00
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5 MG
CHF 216.00
25 MG
CHF 561.00
About This Item
Formula empirica (notazione di Hill):
C26H26ClN2NaO3S2 · xH2O
Numero CAS:
Peso molecolare:
537.07 (anhydrous basis)
Numero MDL:
Codice UNSPSC:
51111800
ID PubChem:
NACRES:
NA.77
Prodotti consigliati
Nome del prodotto
MK-571 sodium salt hydrate, ≥95% (HPLC)
Livello qualitativo
Saggio
≥95% (HPLC)
Stato
powder
Condizioni di stoccaggio
desiccated
Colore
white to beige
Solubilità
H2O: 15 mg/mL, clear
Ideatore
Merck & Co., Inc., Kenilworth, NJ, U.S.
Condizioni di spedizione
wet ice
Temperatura di conservazione
−20°C
Stringa SMILE
O.[Na+].CN(C)C(=O)CCSC(SCCC([O-])=O)c1cccc(\C=C\c2ccc3ccc(Cl)cc3n2)c1
InChI
1S/C26H27ClN2O3S2.Na.H2O/c1-29(2)24(30)12-14-33-26(34-15-13-25(31)32)20-5-3-4-18(16-20)6-10-22-11-8-19-7-9-21(27)17-23(19)28-22;;/h3-11,16-17,26H,12-15H2,1-2H3,(H,31,32);;1H2/q;+1;/p-1/b10-6+;;
MSHRPLRGSQECLY-DOLBFOAYSA-M
Applicazioni
MK-571 sodium salt hydrate has been used:
- as an efflux inhibitor for monitoring multidrug resistance protein (MRP)-function and to avoid redundancy of other transporters[1]
- to assess its effect on cell proliferation and 2D-migration in vitro in various cell lines of glioblastoma multiforme (GBM)[2]
- as multidrug resistance (MDR) transporter inhibitor to study its effects in ovarian cancer cells[3]
- as specific inhibitors of ABCC1/2 to investigate transport, toxicity, flow cytometry and arsenic efflux[4]
Azioni biochim/fisiol
MK 571 is a potent and selective leukotriene D4 (LTD4) antagonist and ABCC multidrug resistance protein 1(MRP1) inhibitor. The cysteinyl leukotrienes (CysLTs), LTC4, LTD4, and LTE4, mediate their actions through two distinct G-protein coupled receptors. LTD4 is the preferred ligand for the CysLT1 receptor, whereas LTC4 and LTD4 bind with approximately equal affinity to the CysLT2 receptor. MK 571 is a selective, orally active CysLT1 receptor antagonist. It blocks the binding of LTD4, but not LTC4, to human and guinea pig lung membranes with Ki values of 0.22 nM and 2.1 nM, respectively. MK 571 effectively blocks LTD4 activation of recombinant human and mouse CysLT1 receptors but is ineffective at blocking LTC4 or LTD4 activation of the recombinant human or murine CysLT2 receptors. It potentially inhibits MRP1 and has been shown to overcome acquired arsenic tolerance.
MK-571 is a potent and selective leukotriene D4 (LTD4) antagonist and ABCC multidrug resistance protein 1(MRP1) inhibitor.
Caratteristiche e vantaggi
This compound is featured on the Leukotriene Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Avvertenze
Warning
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Organi bersaglio
Respiratory system
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
dust mask type N95 (US), Eyeshields, Gloves
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I have a question regarding storage of MK-571 sodium salt hydrate. For how long the powder form can be stored at -20C? Thanks in advance.
1 answer-
Helpful?
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Does MK-571 sodium salt hydrate has to be prepared freshly before experiments or can it be diluted and stored as a stock solution; without affecting the stability? Thanks in advance
1 answer-
Solution stability studies have not been performed on this compound. However, other sources report that the material is stable up tp 6 months when stored in aliquots at -20°C.
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