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M1390

3,3′-Methylene-bis(4-hydroxycoumarin)

Sinonimo/i:

Bishydroxycoumarin, Dicoumarol, Dicumarol

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A voi/SKUDisponibilitàPrezzo
5 g
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CHF 52.90

Informazioni su questo articolo

Formula empirica (notazione di Hill):
C19H12O6
Numero CAS:
66-76-2
Peso molecolare:
336.29
NACRES:
NA.47
PubChem Substance ID:
24896643
UNSPSC Code:
12352103
EC Number:
200-632-9
MDL number:
MFCD00006857

CHF 52.90

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biological source

synthetic (organic)

Quality Segment

100

assay

≥98% (TLC)

form

powder

mp

290-292 °C (lit.)

solubility

pyridine: 50 mg/mL, clear, faintly yellow to brownish-yellow

SMILES string

OC1=C(CC2=C(O)c3ccccc3OC2=O)C(=O)Oc4ccccc14

InChI

1S/C19H12O6/c20-16-10-5-1-3-7-14(10)24-18(22)12(16)9-13-17(21)11-6-2-4-8-15(11)25-19(13)23/h1-8,20-21H,9H2

InChI key

DOBMPNYZJYQDGZ-UHFFFAOYSA-N

Gene Information

human ... CYP2C9(1559), VKORC1(79001)

Biochem/physiol Actions

Prototype of the 4-hydroxycoumarin class of anticoagulants, which act as vitamin K antagonists, preventing formation of prothrombin. There are many reports that dicumarol also inhibits NADPH:quinone oxidoreductase (NQO(1)). In one, it inhibited NQO(1) in a pancreatic cancer cell line, causing increased formation of superoxide and inhibiting cell growth.

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Questo articolo
D5782C9375287897
3,3′-Methylene-bis(4-hydroxycoumarin)

Sigma-Aldrich

M1390

3,3′-Methylene-bis(4-hydroxycoumarin)

2′,3′-Dideoxycytidine ≥98% (HPLC)

Sigma-Aldrich

D5782

2′,3′-Dideoxycytidine

5-Carboxy-2-thiouracil

Sigma-Aldrich

C9375

5-Carboxy-2-thiouracil

Dicoumarol A cell-permeable quinone reductase inhibitor with anticoagulant properties.

Sigma-Aldrich

287897

Dicoumarol

biological source

synthetic (organic)

biological source

synthetic (organic)

biological source

synthetic (organic)

biological source

-

assay

≥98% (TLC)

assay

≥98% (HPLC)

assay

≥98% (TLC)

assay

≥98% (titration)

Gene Information

human ... CYP2C9(1559), VKORC1(79001)

Gene Information

-

Gene Information

-

Gene Information

-

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

100

form

powder

form

powder

form

powder

form

solid

solubility

pyridine: 50 mg/mL, clear, faintly yellow to brownish-yellow

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

solubility

1 M NaOH: 50 mg/mL, clear, colorless to faintly yellow

solubility

0.1 M NaOH: 15 mg/mL, pyridine: 50 mg/mL

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Chronic 2 - STOT RE 1 Oral

Classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificati d'analisi (COA)

Lot/Batch Number

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