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M1323

Sigma-Aldrich

Midostaurin hydrate

≥98% (HPLC), solid, kinase inhibitor

Sinonimo/i:

CGP 41251, N-[(9S,10R,11R,13R)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3′,2′,1′-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methylbenzamide, N-benzoylstaurosporine, PKC-412

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1 MG
CHF 92.60
5 MG
CHF 359.00

CHF 92.60

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1 MG
CHF 92.60
5 MG
CHF 359.00

About This Item

Formula empirica (notazione di Hill):
C35H30N4O4 · xH2O
Numero CAS:
1217450-80-0
Peso molecolare:
570.64 (anhydrous basis)
Numero MDL:
MFCD12828879
Codice UNSPSC:
12352200
ID PubChem:
329817870
NACRES:
NA.77

CHF 92.60

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Nome del prodotto

Midostaurin hydrate, ≥98% (HPLC), solid

Saggio

≥98% (HPLC)

Stato

solid

Colore

off-white

Solubilità

DMSO: >10 mg/mL

Temperatura di conservazione

−20°C

Stringa SMILE

O.CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)[n@@H]3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8[n@H]2c7c35)N(C)C(=O)c9ccccc9

InChI

1S/C35H30N4O4.H2O/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38;/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40);1H2/t25-,26-,32-,35+;/m1./s1
YEKDLUZCCDJYAJ-LJAYRLSQSA-N

Azioni biochim/fisiol

Midostaurin is an inhibitor of tyrosine kinase, protein kinase C, and VEGF.
Midostaurin is an inhibitor of tyrosine kinase, protein kinase C, and VEGF. Midostaurin inhibits cell growth and phosphorylation of FLT3, STAT5, and ERK. Midostaurin is a potent inhibitor of a spectrum of FLT3 activation loop mutations.

Caratteristiche e vantaggi

This compound is featured on the PKC page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pittogrammi

Health hazard
GHS08

Avvertenze

Danger

Indicazioni di pericolo

H360FD

Classi di pericolo

Repr. 1B

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
0000217940
0000217939
0000215881
0000215881
0000217940

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Mahmoud Hallal et al.
BMC cancer, 21(1), 789-789 (2021-07-10)
Despite the introduction of targeted therapies, most patients with myeloid malignancies will not be cured and progress. Genomics is useful to elucidate the mutational landscape but remains limited in the prediction of therapeutic outcome and identification of targets for resistance.
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Protein-templated fragment ligations have been established as a powerful method for the assembly and detection of optimized protein ligands. Initially developed for reversible ligations, the method has been expanded to irreversible reactions enabling the formation of super-additive fragment combinations. Here
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Protein Kinase C (PKC)

Protein kinase C (PKC) is an AGC kinase that phosphorylates serine and threonine residues in many target proteins.

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