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L9545

Sigma-Aldrich

Leukemia Inhibitory Factor human, animal component free

recombinant, expressed in rice, 500 μg/mL

Sinonimo/i:

Leukemia Inhibitory Factor human, LIF, rLIF

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About This Item

Numero MDL:
MFCD00163950
Codice UNSPSC:
12352202
NACRES:
NA.32

Ricombinante

expressed in rice

Saggio

>95% (SDS-PAGE)

Potenza

>1 x 108 units/mg ED<sub>50</sub>

Concentrazione

500 μg/mL

tecniche

cell culture | mammalian: suitable

Impurezze

<0.05 EU/μg endotoxin

N° accesso UniProt

P15018

Condizioni di spedizione

dry ice

Temperatura di conservazione

−70°C

Informazioni sul gene

human ... LIF(3976)

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Categorie correlate

Azioni biochim/fisiol

Leukemia Inhibitory Factor (LIF) is a pleiotropic glycoprotein originally described to inhibit the proliferation of the murine myeloid leukemic cell line M1, while inducing differentiation into macrophages. Other activities were later identified to LIF, which is known by a variety of synonyms, including DIF, D-factor, DIA, DRF, CNDF, HILDA, HSF-III, and MLPLI. Human LIF exerts its actions through a receptor comprising a 190 kDa LIF-binding α-chain (130 kDa, mouse) and a 130 kDa signal-transducing β-chain (gp130), which is shared with CNTF, OSM, L-6 and IL-11. As such, it is a member of the gp130 family of the cytokine receptor superfamily. LIF receptors have been identified on several cells, including monocytes, liver, placenta and embryonic stem cells. Natural LIF is heavily glycosylated, showing an apparent molecular weight of 32 kDa to 62 kDa, depending on the source, but absence of glycosylation appears not to affect its biological activity. A single gene encodes LIF, which is secreted as a single chain glycoprotein containing 180 amino acids for human or mouse with a conserved disulfide bond. Human and mouse LIF share 78% sequence homology. Human LIF can activate mouse cells, but mouse LIF cannot activate human cells.

Stato fisico

0.2 μm filtered solution at 500 μg/mL in buffered saline with 0.02% TWEEN®20

Note legali

TWEEN is a registered trademark of Croda International PLC

Codice della classe di stoccaggio

10 - Combustible liquids

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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Journal of biotechnology, 172, 67-72 (2014-01-02)
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Articoli

Leukemia Inhibitory Factor (LIF) Protein

Leukemia Inhibitory Factor (LIF) is a stem cell growth factor used for the in vitro culture of pluripotent mouse embryonic stem cells (ES cells).

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