Passa al contenuto
Merck
Tutte le immagini(2)

Documenti fondamentali

Visualizza tutta la documentazione

L9133

Sigma-Aldrich

Leucine Enkephalin acetate salt hydrate

≥95% (HPLC)

Sinonimo/i:

Leucine Enkephalin

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Tutte le immagini(2)

About This Item

Formula empirica (notazione di Hill):
C28H37N5O7 · xC2H4O2 · yH2O
Peso molecolare:
555.62 (anhydrous free base basis)
Numero MDL:
MFCD11045938
Codice UNSPSC:
12352209
eCl@ss:
32160409
ID PubChem:
329817669
NACRES:
NA.32
Prezzi e disponibilità al momento non sono disponibili

Livello qualitativo

200

Saggio

≥95% (HPLC)

Temperatura di conservazione

−20°C

Stringa SMILE

O.CC(O)=O.CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc2ccc(O)cc2)C(O)=O

InChI

1S/C28H37N5O7.C2H4O2.H2O/c1-17(2)12-23(28(39)40)33-27(38)22(14-18-6-4-3-5-7-18)32-25(36)16-30-24(35)15-31-26(37)21(29)13-19-8-10-20(34)11-9-19;1-2(3)4;/h3-11,17,21-23,34H,12-16,29H2,1-2H3,(H,30,35)(H,31,37)(H,32,36)(H,33,38)(H,39,40);1H3,(H,3,4);1H2/t21-,22-,23-;;/m0../s1
QKDIOZBQOQJXFR-XQCXOTTHSA-N

Informazioni sul gene

human ... OPRD1(4985) , OPRM1(4988)
mouse ... OPRD1(18386) , OPRM1(18390)
rat ... OPRD1(24613) , OPRM1(25601)

Amino Acid Sequence

Tyr-Gly-Gly-Phe-Leu

Descrizione generale

Leucine Enkephalin is a pentapeptide and is a normal component of central and peripheral tissues.[1] Leucine Enkephalin has amino acid sequence Tyr-Gly-Gly-Phe-Leu and is distributed in the brains of many animals, including humans.[2] It is an endogenous opioid neurotransmitter/neuromodulator localized in brain parallels and in δ receptors.

Applicazioni

Leucine Enkephalin acetate salt hydrate has been used in the calibration of the Q-Tof Micro hybrid, triple quadrupole-orthogonal acceleration time of flight (TOF) instrument in single-stage TOF mode.[3] It has also been used to perform the calibration of mass spectrometry.[4] It has also been used in liquid chromatography-mass spectrometry (LCMS)/MS for calibration of the system and for relative correction of the spectra.[5][4]

Azioni biochim/fisiol

Leucine Enkephalin (LEU-ENK) functions as agonists at both μ- and δ-opioid receptor sites.[1][2] It might also play a role as neurotransmitter agent at morphine-sensitive synapses.[1] Leucine Enkephalin is also associated with pain regulation.[6] LEU-ENK expressed in camel lacrimal nerve regulates lacrimal fluid and protein secretion.[7] LEU-ENK is degraded during metabolism by several enzymes, including aminopeptidase-N (APN), neutral endopeptidase (NEP), dipeptidyl peptidase- 3 (DPP3), carboxy peptidase-A6 (CPA-6) and angiotensin converting enzyme (ACE), which are sometimes referred to as enkephalinases.[2]

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Scegli una delle versioni più recenti:

Certificati d'analisi (COA)

Lot/Batch Number
0000399198
0000399198
0000420149
0000420149
0000388527

Non trovi la versione di tuo interesse?

Se hai bisogno di una versione specifica, puoi cercare il certificato tramite il numero di lotto.

Cerca un COA

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

I clienti hanno visto anche

Slide 1 of 8

1 of 8

Dynorphin A porcine ≥95% (HPLC)

Sigma-Aldrich

D8147

Dynorphin A porcine

β-Endorphin rat ≥97% (HPLC)

Sigma-Aldrich

E1142

β-Endorphin rat

Met-Arg-Phe-Ala acetate salt ≥90% (HPLC)

Sigma-Aldrich

M1170

Met-Arg-Phe-Ala acetate salt

Bradykinin analytical standard

Supelco

90834

Bradykinin

β-Endorphin human ≥95% (HPLC)

Sigma-Aldrich

E6261

β-Endorphin human

[D-Ala2, N-Me-Phe4, Gly5-ol]-Enkephalin acetate salt ≥97% (HPLC)

Sigma-Aldrich

E7384

[D-Ala2, N-Me-Phe4, Gly5-ol]-Enkephalin acetate salt

Bradykinin powder, ≥98% (HPLC)

Sigma-Aldrich

B3259

Bradykinin

Substance P acetate salt hydrate ≥95% (HPLC), powder

Sigma-Aldrich

S6883

Substance P acetate salt hydrate

J Hughes et al.
Nature, 258(5536), 577-580 (1975-12-18)
Enkephalin, a natural ligand for opiate receptors is composed of the pentapepides H-Tyr-Gly-Gly-Phe-Met-OH and H-Tyr-Gly-Gly-Phe-Leu-OH. The evidence is based on the determination of the amino acid sequence of natural enkephalin by the dansyl-Edman procedure and by mass spectrometry followed by
S R George et al.
The Journal of biological chemistry, 275(34), 26128-26135 (2000-06-08)
The existence of dimers and oligomers for many G protein-coupled receptors has been described by us and others. Since many G protein-coupled receptor subtypes are highly homologous to each other, we examined whether closely related receptors may interact with each
F Bolacchi et al.
Neurochemical research, 21(8), 875-884 (1996-08-01)
The hydrolysis of leucine enkephalin by the proteolytic enzymes present in human and rabbit plasma has been studied by kinetic and chromatographic techniques. Data obtained indicate the existence of noticeable intraspecific differences in the kinetics of leu-enkephalin degradation, and of
A P Sayani et al.
Journal of pharmaceutical sciences, 82(11), 1179-1185 (1993-11-01)
Leucine enkephalin (Tyr-Gly-Gly-Phe-Leu; Leu-Enk) is a naturally occurring peptide that has been shown to have pain modulating properties. To evaluate the feasibility of using various absorptive mucosae as a route of systemic delivery, the stability of Leu-Enk and the effect
An enzyme-linked immunosorbent assay for detecting 3-phenoxybenzoic acid in plasma and its application in farmers and consumers.
Thiphom S
Analytical Methods : Advancing Methods and Applications, 4(11), 3772-3778 (2012)
Visualizza tutti i documenti correlati

Questions

Reviews

No rating value

Active Filters

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.