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L6004

Sigma-Aldrich

Lincomycin hydrochloride

≥90% (TLC)

Sinonimo/i:

Epilincomycin, Lincomycin HCL, Lincocin hydrochloride, Methyl 6,8-dideoxy-6-(1-methyl-4-propyl-2-pyrrolidinecarboxamido)-1-thio-D-erythro-α-D-galactooctopyranoside hydrochloride

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About This Item

Formula empirica (notazione di Hill):
C18H34N2O6S · HCl
Numero CAS:
859-18-7
Peso molecolare:
443.00
Beilstein:
4171650
Numero CE:
212-726-7
Numero MDL:
MFCD00083647
Codice UNSPSC:
51284507
ID PubChem:
329817633
NACRES:
NA.85
Prezzi e disponibilità al momento non sono disponibili

Saggio

≥90% (TLC)

Potenza

800-900 units per mg

Colore

white to faint yellow

Solubilità

H2O: soluble 50 mg/mL

Spettro attività antibiotica

Gram-positive bacteria

Modalità d’azione

protein synthesis | interferes

Temperatura di conservazione

2-8°C

Stringa SMILE

Cl.CCC[C@@H]1C[C@H](N(C)C1)C(=O)N[C@H]([C@@H](C)O)[C@H]2O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O

InChI

1S/C18H34N2O6S.ClH/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4;/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25);1H/t9-,10-,11+,12-,13+,14-,15-,16-,18-;/m1./s1
POUMFISTNHIPTI-BOMBIWCESA-N

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Categorie correlate

Descrizione generale

Chemical structure: macrolide

Applicazioni

Lincomycin hydrochloride is an antibiotic used to study the inhibition of protein synthesis, bacterial antibiotic resistance, and protein and surfactant binding [1][2] It is produced by Streptomyces lincolnensis var. lincolnensis.

Azioni biochim/fisiol

Mode of action: Lincomycin inhibits bacterial protein synthesis by forming cross-links within the peptidyl transferase loop region of the 23S rRNA.†

Antimicrobial spectrum: Lincomycin hydrochloride is effective against gram-positive bacteria.

Nota sulla preparazione

This product is soluble in water at 50 mg/mL, yielding a clear, colorless solution.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H315,H319,H335

Classi di pericolo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
112K0566
WXBF4028V
WXBF1860V
WXBF0162V
WXBD7899V

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Neelam Keswani et al.
Journal of biochemistry, 148(1), 71-84 (2010-04-02)
The thermodynamics of interaction of neomycin and lincomycin with bovine serum albumin (BSA) and human serum albumin (HSA) has been studied using isothermal titration calorimetry (ITC), in combination with UV-visible, steady state and time resolved fluorescence spectroscopic measurements. Neomycin is
Charlotte M M Gommers et al.
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When germinating in the light, Arabidopsis (Arabidopsis thaliana) seedlings undergo photomorphogenic development, characterized by short hypocotyls, greening, and expanded cotyledons. Stressed chloroplasts emit retrograde signals to the nucleus that induce developmental responses and repress photomorphogenesis. The nuclear targets of these
H Malke et al.
Antimicrobial agents and chemotherapy, 19(1), 91-100 (1981-01-01)
The phenomenon of zonal resistance to lincomycin, which is characteristic of most clinical isolates with lincomycin resistance in Streptococcus pyogenes, has been studied. These strains grow within a defined concentration range of lincomycin (approximately 60 to 200 microgram/ml), or at
Kazunori Miyata et al.
Photosynthesis research, 113(1-3), 165-180 (2012-07-17)
When visible light is excess, the photosynthetic machinery is photoinhibited. The extent of net photoinhibition of photosystem II (PSII) is determined by a balance between the rate of photodamage to D1 and some other PSII proteins and the rate of
Phillip A Davis et al.
Photosynthesis research, 112(3), 153-161 (2012-06-15)
Plants use light to fix carbon through the process of photosynthesis but light also causes photoinhibition, by damaging photosystem II (PSII). Plants can usually adjust their rate of PSII repair to equal the rate of damage, but under stress conditions
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Articoli

Inhibition of Protein Synthesis by Antibiotics

Antibiotics targeting bacterial ribosomes disrupt protein synthesis, a key process in bacterial growth inhibition.

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