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L4021

Sigma-Aldrich

Prolactin human

recombinant, expressed in E. coli, lyophilized powder, BioReagent, suitable for cell culture, >97% (SDS-PAGE)

Sinonimo/i:

hPRL, LTH, Lactogenic Hormone, Luteotropic Hormone, PRL

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50 μG
CHF 422.00

CHF 422.00

Spedizione prevista il12 aprile 2025

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50 μG
CHF 422.00

About This Item

Numero CAS:
9002-62-4
Numero MDL:
MFCD00131553
Codice UNSPSC:
51111800
NACRES:
NA.77
Origine biologica:
Escherichia coli
Stato:
lyophilized powder
Saggio:
>97% (SDS-PAGE)

CHF 422.00

Spedizione prevista il12 aprile 2025

Richiedi un ordine bulk

Origine biologica

Escherichia coli

Livello qualitativo

200

Ricombinante

expressed in E. coli

Descrizione

200 amino acid residue methionyl form of mature, recombinant human prolactin (amino acid residues 29-227).

Nome Commerciale

BioReagent

Saggio

>97% (SDS-PAGE)

Stato

lyophilized powder

Potenza

0.030-0.300 ng/mL EC50

PM

predicted mol wt ~24 kDa

tecniche

cell culture | mammalian: suitable

Impurezze

endotoxin, tested

Solubilità

water: 0.5000 mL, clear, colorless

N° accesso UniProt

P01236

Condizioni di spedizione

ambient

Temperatura di conservazione

−20°C

Informazioni sul gene

human ... PRL(5617)

Applicazioni

Use in cell culture applications to study prolactin regulation of cell signaling and gene expression.

Azioni biochim/fisiol

Neuroendocrine hormone; belongs to the cytokine hematopoietic receptor family; induces lactation; inhibits secretion of gonadotropins; release is inhibited by dopamine.
Prolactin is a neuroendocrine hormone. The prolactin receptor is a transmembrane glycoprotein that belongs to the cytokine hematopoietic receptor family. A large number of cells and organs express the receptor, including B cells, T cells, macrophages, monocytes, and neutrophils. Prolactin signal transduction involves the JAK/STAT families and the src kinase family. Induces lactation; inhibits secretion of gonadotropins; release is inhibited by dopamine.

Altre note

Contains an N-terminal methionine not present in the natural product.

Stato fisico

Lyophilized from a solution in 10 mM phosphate and 50 mM sodium chloride, pH 8.0.

Ricostituzione

It is recommended that sterile 4 mM HCl containing 1 mg/mL bovine serum albumin be added to the vial to prepare a stock solution of no less than 100 μg/mL.

Risultati analitici

The biological activity is assayed by proliferation of the rat lymphoma cell line, Nb2-11.

Pittogrammi

Health hazard
GHS08

Avvertenze

Danger

Indicazioni di pericolo

H360

Consigli di prudenza

P201 - P308 + P313

Classi di pericolo

Repr. 1B

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
0000395794
0000395794
0000214018
0000214018
099M4151V

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G Bellone et al.
Journal of cellular physiology, 163(2), 221-231 (1995-05-01)
The pituitary hormone prolactin (Prl) is known to act as a local regulator of immune cell function, and Prl-binding receptors (Prl-R) have been described to share distinctive features with the members of the newly described cytokine/hemopoietin receptor superfamily. Here we
Extrapituitary prolactin: distribution, regulation, functions, and clinical aspects.
N Ben-Jonathan et al.
Endocrine reviews, 17(6), 639-669 (1996-12-01)
Julien Auffret et al.
American journal of physiology. Endocrinology and metabolism, 305(10), E1309-E1318 (2013-09-26)
Prolactin (PRL) and placental lactogens stimulate β-cell replication and insulin production in pancreatic islets and insulinoma cells through binding to the PRL receptor (PRLR). However, the contribution of PRLR signaling to β-cell ontogeny and function in perinatal life and the
Massimo Costanza et al.
Journal of immunology (Baltimore, Md. : 1950), 191(5), 2082-2088 (2013-07-26)
Predominance of multiple sclerosis (MS) in women, reductions of disease flares during pregnancy, and their increase in the postpartum period have suggested a hormonal influence on MS activity. The hormone prolactin (PRL) has long been debated as a potential immune-stimulating
Bibiana Moreno-Carranza et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 305(7), R720-R726 (2013-08-21)
Prolactin (PRL) is a potent liver mitogen and proangiogenic hormone. Here, we used hyperprolactinemic rats and PRL receptor-null mice (PRLR(-/-)) to study the effect of PRL on liver growth and angiogenesis before and after partial hepatectomy (PH). Liver-to-body weight ratio
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