HPA043237

Anti-APOBEC3A antibody produced in rabbit

Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

• Sinonimo/i: Anti-Apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3a, Anti-Arp3, Anti-Phrbn
• Codice UNSPSC: 12352203
• Numero Human Protein Atlas: HPA043237

Proprietà

• Origine biologica: rabbit
• Coniugato: unconjugated
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Nome Commerciale: Prestige Antibodies^® Powered by Atlas Antibodies
• Forma fisica: buffered aqueous glycerol solution
• Reattività contro le specie: human
• Convalida avanzata: recombinant expression; orthogonal RNAseq; Learn more about Antibody Enhanced Validation
• tecniche: immunohistochemistry: 1:1000-1:2500; western blot: 0.04-0.4 μg/mL
• Sequenza immunogenica: EASPASGPRHLMDPHIFTSNFNNGIGR
• N° accesso UniProt: P31941
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... APOBEC3A(200315)

Descrizione

Descrizione generale

The gene APOBEC3A (apolipoprotein B mRNA editing enzyme catalytic subunit 3A) is mapped to human chromosome 22q13.1. The protein has a catalytically active deaminase domain. It belongs to the APOBEC3 genes family.

Immunogeno

apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A recombinant protein epitope signature tag (PrEST)

Applicazioni

All Prestige Antibodies^®Powered by Atlas Antibodies is developed and validated by the Human Protein Atlas (HPA) project . Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.
Anti-APOBEC3A antibody produced in rabbit has been used in immunohistochemistry.

Anti-APOBEC3A antibody produced in rabbit has also been used in immunofluorescence staining.

Azioni biochim/fisiol

APOBEC3A (apolipoprotein B mRNA editing enzyme catalytic subunit 3A) is a cytidine deaminase. APOBEC3 proteins are mainly involved in intracellular antiviral defense responses, particularly against retroviruses. They are also involved in carcinogenesis by dC (deoxycytidine) deamination, thereby causing DNA mutations. APOBEC3A also exhibits mRNA-editing function. It is involved with guanine-to-alanine editing in transcripts of WT1 (wilms tumor 1). Deletion in APOBEC3A gene is associated with breast cancer predisposition. This happens due to increased stability of APOBEC3A mRNA.

Caratteristiche e vantaggi

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Linkage

Corresponding Antigen APREST83236

Stato fisico

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

Note legali

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1