G9797
GW9508
≥98% (HPLC)
Sinonimo/i:
4-(3-Phenoxybenzylamino)phenylpropionic acid
Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Scegli un formato
5 MG
CHF 145.00
25 MG
CHF 565.00
Scegli un formato
Cambia visualizzazione
5 MG
CHF 145.00
25 MG
CHF 565.00
About This Item
Formula empirica (notazione di Hill):
C22H21NO3
Numero CAS:
Peso molecolare:
347.41
Numero MDL:
Codice UNSPSC:
51111800
ID PubChem:
NACRES:
NA.25
Prodotti consigliati
Livello qualitativo
Saggio
≥98% (HPLC)
Stato
powder
Colore
white
Solubilità
DMSO: >20 mg/mL
Temperatura di conservazione
2-8°C
Stringa SMILE
OC(=O)CCc1ccc(NCc2cccc(Oc3ccccc3)c2)cc1
InChI
1S/C22H21NO3/c24-22(25)14-11-17-9-12-19(13-10-17)23-16-18-5-4-8-21(15-18)26-20-6-2-1-3-7-20/h1-10,12-13,15,23H,11,14,16H2,(H,24,25)
DGENZVKCTGIDRZ-UHFFFAOYSA-N
Applicazioni
GW9508 has been used in:
- cell proliferation assay in pancreatic cancer cells[1]
- in motility assay in melanoma cells[2]
- cell invasion assay in colon cancer cells[3]
GW9508, a selective FFA1/GPR40 agonist, may be used to differentiate and characterize the free fatty acid receptor FFA1/GPR40. GW9508 is used to study the role of FFA1/GPR40 receptors in processes such as the free fatty acid enhancement of glucose-stimulated insulin release and type 2 diabetes. GW9508 is used to study the process by which FFA1/GPR40 receptors protect from ovariectomy-induced bone loss in vivo though inhibition of osteoclast differentiation and suppress complete Freund′s adjuvant (CFA)-Induced inflammatory chronic pain.[4][5]
Azioni biochim/fisiol
GW9508 is a selective FFA1/GPR40 agonist. GPR40 was formerly an orphan G protein-coupled receptor whose endogenous ligands have now been identified as free fatty acids (FFAs). The receptor, named FFA receptor 1, has been implicated in the pathophysiology of type 2 diabetes and is a drug target because of its role in FFA-mediated enhancement of glucose-stimulated insulin release. GW9508 showed greater than 500-fold selectivity for GPR40 over GPR41 and GPR43 and possessed a good in vitro and in vivo profile with excellent bioavailability. GW9508 stimulated intracellular Ca2+ mobilization in human embryonic kidney HEK-293 cells expressing GPR40 or GPR120, but not in the parent HEK-293 cell line. GW9508 dose dependently potentiated glucose-stimulated insulin secretion in MIN6 cells, but not in primary rat or mouse islets. GW9508 potentiates the KCl-mediated increase in insulin secretion in MIN6 cells.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Dispositivi di protezione individuale
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Scegli una delle versioni più recenti:
Possiedi già questo prodotto?
I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
I clienti hanno visto anche
Chiori Yabuki et al.
PloS one, 8(10), e76280-e76280 (2013-10-17)
Selective free fatty acid receptor 1 (FFAR1)/GPR40 agonist fasiglifam (TAK-875), an antidiabetic drug under phase 3 development, potentiates insulin secretion in a glucose-dependent manner by activating FFAR1 expressed in pancreatic β cells. Although fasiglifam significantly improved glycemic control in type
Habtamu Wondifraw Baynes et al.
Adipocyte, 7(2), 81-87 (2018-03-15)
Polyunsaturated Fatty acids have multiple effects in peripheral tissues and pancreatic beta cell function. The n-3 Polyunsaturated Fatty acids prevent and reverse high-fat-diet induced adipose tissue inflammation and insulin resistance. Insulin secretion is stimulated by glucose, amino acids, and glucagon-
Jie Xiao et al.
Journal of neuroinflammation, 18(1), 160-160 (2021-07-20)
Germinal matrix hemorrhage (GMH) is defined by the rupture of immature blood vessels in the germinal matrix, where subsequent hemorrhage enters the subependymal zone and the cerebral lateral ventricles. The consequent blood clot has been identified as the causative factor
Yufeng Zhao et al.
PloS one, 8(4), e60255-e60255 (2013-04-09)
The role of the free fatty acid (FFA) receptor and the intracellular metabolites of linoleic acid (LA) in LA-stimulated increase in cytosolic free calcium concentration ([Ca(2+)]i) was investigated. [Ca(2+)]i was measured using Fura-2 as indicator in rat pancreatic β-cells in
Yuhang Gong et al.
Neuropharmacology, 164, 107899-107899 (2019-12-07)
GPR40 was utilized as the drug target to the treatment of diabetes, but the function and mechanisms ameliorating the Alzheimer's disease (AD) remain unknown. In present study, the typical APP/PS1 mouse model was applied to explore the function and mechanism
Active Filters
Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..
Contatta l'Assistenza Tecnica.
