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G5918

Sigma-Aldrich

GR 113808

≥98% (HPLC), solid

Sinonimo/i:

1-[2-[(Methylsulfonyl)-amino]ethyl]-4-piperidinyl]methyl 1-methyl-1H-indole-3-carboxylate

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10 MG
CHF 187.00
50 MG
CHF 658.00

CHF 187.00

Spedizione prevista il29 maggio 2025

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10 MG
CHF 187.00
50 MG
CHF 658.00

About This Item

Formula empirica (notazione di Hill):
C19H27N3O4S
Numero CAS:
144625-51-4
Peso molecolare:
393.50
Numero MDL:
MFCD00912901
Codice UNSPSC:
12352200
ID PubChem:
24278311
NACRES:
NA.77

CHF 187.00

Spedizione prevista il29 maggio 2025

Richiedi un ordine bulk

Saggio

≥98% (HPLC)

Stato

solid

Colore

white to light pink

Solubilità

DMSO: >20 mg/mL

Ideatore

GlaxoSmithKline

Temperatura di conservazione

2-8°C

Stringa SMILE

Cn1cc(C(=O)OCC2CCN(CCNS(C)(=O)=O)CC2)c3ccccc13

InChI

1S/C19H27N3O4S/c1-21-13-17(16-5-3-4-6-18(16)21)19(23)26-14-15-7-10-22(11-8-15)12-9-20-27(2,24)25/h3-6,13,15,20H,7-12,14H2,1-2H3
MOZPSIXKYJUTKI-UHFFFAOYSA-N

Informazioni sul gene

human ... HTR4(3360)
rat ... Htr3a(79246) , Htr4(25324)

Applicazioni

GR 113808 has been used as a serotonin receptor 4 (5-HT4R) blocker to study its effects on the calcium (Ca2+) transients in rat ventricular cardiomyocytes.[1] It has also been used as a 5-HT4R antagonist to study its effects on de novo enteric neurogenesis in post-embryonic zebrafish.[2]

Azioni biochim/fisiol

GR 113808 is a 5-HT4 serotonin receptor antagonist.

Caratteristiche e vantaggi

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Note legali

Sold for research purposes under agreement from Glaxo­Smith­Kline

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Scegli una delle versioni più recenti:

Certificati d'analisi (COA)

Lot/Batch Number
BGBC4521
128K4613V
128K46132
128K46131
128K4613

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Sigma-Aldrich

Sigma-Aldrich

H6648

Hanks′ Balanced Salt solution

Poli(etilenglicole) 400, for synthesis

Sigma-Aldrich

8.07485

Poli(etilenglicole)

Dispase® II (neutral protease, grade II) lyophilized, from bacterial, Roche, pkg of 5 × 1 g

Roche

04942078001

Dispase® II (neutral protease, grade II)

B Godínez-Chaparro et al.
Neuroscience, 222, 379-391 (2012-07-17)
In the present study we determined the role of spinal 5-hydroxytriptamine (5-HT) and 5-HT(4/6/7) receptors in the long-term secondary mechanical allodynia and hyperalgesia induced by formalin in the rat. Formalin produced acute nociceptive behaviors (flinching and licking/lifting) followed by long-term
A N James et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 17(1), 76-82 (2005-01-27)
Selective serotonin reuptake inhibitors (SSRIs) are increasingly used to treat a variety of disorders but have gastrointestinal side-effects. To determine the effects of the SSRI, fluoxetine, on gastric smooth muscle contractility. Fundic, antral, and pyloric circular muscle contractility of guinea
J Kamei et al.
Neuroscience, 174, 224-233 (2010-11-18)
Respiratory depression is the most well-known and dangerous side-effect of opioid analgesics. Clinical investigations have revealed that this opioid-induced respiratory depression is less severe in patients with chronic pain, but the mechanisms that underlie this phenomenon are unknown. Therefore, the
M Cachard-Chastel et al.
British journal of pharmacology, 150(7), 883-892 (2007-02-28)
A strategy to treat Alzheimer's disease (AD) is to increase the soluble form of amyloid precursor protein (sAPPalpha), a promnesic protein, in the brain. Because strong evidence supports beneficial effects of 5-hydroxytryptamine 5-HT(4) receptor agonists in memory and learning, we
I Gribovskaja-Rupp et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 24(5), 472-478 (2012-02-07)
Colonic dysfunction occurs after pelvic autonomic nerve damage. The enteric nervous system can compensate. We investigated the role of mucosal serotonin receptors, 5-HT(3) and 5-HT(4) , in the colonic motility restoration over 2 weeks after parasympathetic pelvic nerve transection in
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