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G5173

Sigma-Aldrich

Garcinol

≥95%

Sinonimo/i:

(1R,5R,7R)-3-(3,4-Dihydroxybenzoyl)-4-hydroxy-8,8-dimethyl-1,7-bis(3-methyl-2-buten-1-yl)-5-[(2S)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-Bicyclo[3.3.1]non-3-ene-2,9-dione, Camboginol

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About This Item

Formula empirica (notazione di Hill):
C38H50O6
Numero CAS:
78824-30-3
Peso molecolare:
602.80
Numero MDL:
MFCD03700761
Codice UNSPSC:
12352200
ID PubChem:
329799938

Saggio

≥95%

Stato

powder

Colore

yellow

Solubilità

>5 mg/mL

Temperatura di conservazione

−20°C

Stringa SMILE

C\C(C)=C\C[C@@H](C[C@@]12C[C@@H](C\C=C(\C)C)C(C)(C)[C@@](C\C=C(/C)C)(C(=O)C(=C1O)C(=O)c3ccc(O)c(O)c3)C2=O)C(C)=C

InChI

1S/C38H50O6/c1-22(2)11-13-27(25(7)8)20-37-21-28(15-12-23(3)4)36(9,10)38(35(37)44,18-17-24(5)6)34(43)31(33(37)42)32(41)26-14-16-29(39)30(40)19-26/h11-12,14,16-17,19,27-28,39-40,42H,7,13,15,18,20-21H2,1-6,8-10H3/t27-,28+,37+,38-/m0/s1
QDKLRKZQSOQWJQ-SMDXAGPFSA-N

Azioni biochim/fisiol

Garcinol is a HAT (histone acetyltransferase) inhibitor. Garcinol is anti-inflammatory and anti-carcinogenic. Histone acetyltransferases provide opposing enzymatic mechanisms for chromatin remodeling and epigenetic control of gene expression. HATs are involved in regulation of transformation, transcription, differentiation, apoptosis, embryonic development and oncogenesis. IC50 p300 = 7 mM; IC50 PCAF = 5 mM (similar to anacardic acid). Garcinol is highly toxic compared to LTK-14, and does not discriminate between p300 and PCAF.
Garcinol is a HAT (histone acetyltransferase) inhibitor; anti-inflammatory; anti-carcinogenic.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
020M47231V
020M4723
089K47061
089K4706

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Chandra Sekhar Rao Kadiyala et al.
The Journal of biological chemistry, 287(31), 25869-25880 (2012-06-01)
Histone acetylation was significantly increased in retinas from diabetic rats, and this acetylation was inhibited in diabetics treated with minocycline, a drug known to inhibit early diabetic retinopathy in animals. Histone acetylation and expression of inflammatory proteins that have been
Takahiro Oike et al.
International journal of radiation oncology, biology, physics, 84(3), 815-821 (2012-03-16)
Non-homologous end joining (NHEJ), a major pathway used to repair DNA double-strand breaks (DSBs) generated by ionizing radiation (IR), requires chromatin remodeling at DSB sites through the acetylation of histones by histone acetyltransferases (HATs). However, the effect of compounds with
Chih-Hsiung Wu et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 17(11), 3533-3541 (2011-03-30)
The nicotinic acetylcholine receptor (nAChR) was first characterized in 1970 as a membrane receptor of a neurotransmitter and an ion channel. nAChRs have been shown to be involved in smoking-induced cancer formation in multiple types of human cancer cells. In
Zaorui Zhao et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(7), 2344-2351 (2012-03-08)
Histone acetylation has recently been implicated in learning and memory processes, yet necessity of histone acetylation for such processes has not been demonstrated using pharmacological inhibitors of histone acetyltransferases (HATs). As such, the present study tested whether garcinol, a potent
Aamir Ahmad et al.
Molecular cancer therapeutics, 11(10), 2193-2201 (2012-07-24)
Anticancer properties of Garcinia indica-derived garcinol are just beginning to be elucidated. We have earlier reported its cancer cell-specific induction of apoptosis in breast cancer cells, which was mediated through the downregulation of NF-κB signaling pathway. To gain further mechanistic
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