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G5035

Sigma-Aldrich

Granulocyte-Macrophage Colony-Stimulating Factor human

GM-CSF, recombinant, expressed in E. coli, suitable for cell culture

Sinonimo/i:

GM-CSF human

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About This Item

Numero MDL:
MFCD00166611
Codice UNSPSC:
12352202
NACRES:
NA.77

Origine biologica

human

Livello qualitativo

200

Ricombinante

expressed in E. coli

Saggio

≥98% (SDS-PAGE)

Forma fisica

lyophilized powder

Potenza

≤0.1 ng/mL EC50

PM

14.6 kDa

Confezionamento

pkg of 4X5 μg
pkg of 5 μg

Condizioni di stoccaggio

avoid repeated freeze/thaw cycles

tecniche

cell culture | mammalian: suitable

Impurezze

≤1.000 EU/μg

Colore

white

Solubilità

water: soluble 0.010 mL, clear, colorless

N° accesso UniProt

P04141

Temperatura di conservazione

−20°C

Informazioni sul gene

human ... CSF2(1437) , CSF2(1437)

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Descrizione generale

Package size based on protein content

Azioni biochim/fisiol

Granulocyte-macrophage colony stimulating factor (GM-CSF) is a growth and differentiation factor for cells in the granulocyte, macrophage and eosinophil lineage. GM-CSF stimulates colony formation from pluripotential progenitor cells at extremely low concentrations and is an essential survival and proliferative factor for hematopoietic progenitor cells in all divisions up to maturity. It also stimulates growth in some epithelial cells and osteoclasts. GM-CSF is produced by a variety of cell types (monocytes, endothelial cells, T-cells, fibroblasts, mitogen-stimulated B-cells, and LPS-stimulated macrophages). GM-CSF is secreted as a single chain glycoprotein containing 128 amino acids for human with a conserved disulfide bond. Human and murine GM-CSF share approx. 54% sequence homology and do not cross-react in bioactivity.

Stato fisico

Lyophilized from a 0.2 μm filtered, 10 mM sodium citrate, pH 3.5 solution.

Risultati analitici

The proliferative activity of human GM-CSF is tested in culture using human TF-1 cells.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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