G2392

Disialoganglioside GD_1a from bovine brain

≥95% (TLC), lyophilized powder

• Sinonimo/i: Ganglioside GD_1a, disialo from bovine brain
• Numero CAS: 12707-58-3
• Beilstein: 6228822
• Numero MDL: MFCD00130960
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Livello qualitativo: 200
• Saggio: ≥95% (TLC)
• Stato: lyophilized powder
• Solubilità: DMSO: soluble
• Temperatura di conservazione: −20°C
• InChI: 1S/C86H152N4O39.2Na/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-51(100)50(90-60(105)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2)46-118-80-69(111)67(109)72(57(43-94)120-80)123-82-71(113)78(129-86(84(116)117)39-53(102)62(88-48(4)98)77(128-86)65(107)55(104)41-92)74(59(45-96)122-82)124-79-63(89-49(5)99)75(66(108)56(42-93)119-79)125-81-70(112)68(110)73(58(44-95)121-81)126-85(83(114)115)38-52(101)61(87-47(3)97)76(127-85)64(106)54(103)40-91;;/h34,36,50-59,61-82,91-96,100-104,106-113H,6-33,35,37-46H2,1-5H3,(H,87,97)(H,88,98)(H,89,99)(H,90,105)(H,114,115)(H,116,117);;/q;2*+1/p-2/b36-34+;;/t50-,51+,52?,53?,54-,55-,56?,57?,58?,59?,61+,62+,63?,64-,65-,66?,67?,68?,69?,70?,71?,72?,73?,74?,75?,76?,77?,78?,79?,80?,81?,82?,85?,86?;;/m0../s1; CWLDKTAXQZEVQN-CUEXFKMESA-L

Descrizione

Amino Acid Sequence

Cer-Glc-Gal(NeuAc)-GalNAc-Gal-NeuAc

Descrizione generale

Gangliosides are in the neuronal cell membranes and endoplasmic reticulum. They consist of a sialylated polysaccharide chain linked via β-glycosidic linkage to ceramide.[1] They are also located in body fluids and plasma.[2] GD_1a consists of a neutral tetrasaccharide core with one sialic acid on the internal galactose and another sialic acid on the non-reducing terminal galactose.[3]

Applicazioni

Disialoganglioside GD_1a from bovine brain has been used:

• as a receptor for the detection of murine norovirus-1 (MNV-1) by RT-PCR[4]
• as a glycolipid to study the interaction between protein human endogenous retrovirus W family pHERV-W ENV and glycolipids by enzyme-linked immunosorbent assay (ELISA)[5]
• as a reference standard to analyze the ganglioside signatures of prostate cancer cells by high-performance liquid chromatography[6]

Azioni biochim/fisiol

Gangliosides are involved in cellular functions such as the differentiation of neurons, formation of axons, synapses,[7] cell proliferation, differentiation, adhesion, and cell death.[2] In addition, gangliosides form microdomains on the outer surface of the cell membranes that are involved in signal transduction and help in the formation of dendrites.[7] Gangliosides act as Ca²⁺ binding co-factors during synaptic transmission.[2]

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable