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G1895

Sigma-Aldrich

Gly-Pro-Arg-Pro

≥95% (HPLC)

Sinonimo/i:

GPRP, Glycyl-Prolyl-Arginyl-Proline amide

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5 MG
CHF 127.00
25 MG
CHF 430.00

CHF 127.00


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5 MG
CHF 127.00
25 MG
CHF 430.00

About This Item

Formula empirica (notazione di Hill):
C18H31N7O5
Numero CAS:
Peso molecolare:
425.48
Numero MDL:
Codice UNSPSC:
12352209
ID PubChem:
NACRES:
NA.32

CHF 127.00


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Livello qualitativo

Saggio

≥95% (HPLC)

N° accesso UniProt

Temperatura di conservazione

−20°C

Stringa SMILE

NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N2CCC[C@H]2C(O)=O

InChI

1S/C18H31N7O5/c19-10-14(26)24-8-2-5-12(24)15(27)23-11(4-1-7-22-18(20)21)16(28)25-9-3-6-13(25)17(29)30/h11-13H,1-10,19H2,(H,23,27)(H,29,30)(H4,20,21,22)/t11-,12-,13-/m0/s1
WXPZDDCNKXMOMC-AVGNSLFASA-N

Informazioni sul gene

human ... FN1(2335)
mouse ... FN1(14268)
rat ... FN1(25661)

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Amino Acid Sequence

Gly-Pro-Arg-Pro

Descrizione generale

Gly-Pro-Arg-Pro is a peptide that mimics the N-terminal Gly-Pro-Arg region in the α chain of fibrin protein.[1]

Applicazioni

Gly-Pro-Arg-Pro (GPRP) has been used for the formation of crystal composed of GPRP and the 30kDa C-terminal fragment from the γ chain of fibrinogen (rFbgγC30), cloned and expressed in Pichia pastoris.[1]

Azioni biochim/fisiol

Gly-Pro-Arg-Pro (GPRP) is capable of increasing free thrombin.[2] Thus it can be utilized to make thrombin-degranulated platelets, which helps in studying platelet reactions.[3]
Gly-Pro-Arg-Pro peptide suppresses the early steps of fibrin polymerization. The amide derivative of this peptide prevents the degradation of fibrinogen and fragment D by plasmin, even in the presence of EGTA (ethylene glycol-bis (β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid).[4]
Inhibits fibrin polymerization.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)


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B Shenkman et al.
The Journal of laboratory and clinical medicine, 135(1), 43-51 (2000-01-19)
Recent studies emphasize the role of blood constituents in Staphylococcus aureus (S. aureus) adherence to subendothelial extracellular matrix. In the present study, the adherence of two strains of S. aureus (ATCC 29213 and RN 6390) grown to a postexponential phase
N Li et al.
European journal of haematology, 65(1), 57-65 (2000-07-29)
A flow cytometric assay for measurements of leukocyte CD11b expression in whole blood has been developed and evaluated. The method is based on triggering of the flow cytometer by a fluorescent pan leukocyte marker, RPE-CD45. This enabled flow cytometric analysis
The use of the synthetic peptide, Gly-Pro-Arg-Pro, in the preparation of thrombin-degranulated rabbit platelets
Harfenist EJ, et al.
Blood, 59(5), 952-955 (1982)
Katharina Neubauer et al.
Cytoskeleton (Hoboken, N.J.), 76(1), 131-136 (2018-07-19)
Hereditary neuralgic amyotrophy (HNA) is an autosomal dominant disorder associated with episodic, recurrent, and painful neuropathies affecting the nerves of the brachial plexus. In this study, we report on a family of Lebanese descent with HNA onset in early childhood.
U Haddeland et al.
Thrombosis and haemostasis, 75(2), 326-331 (1996-02-01)
The present paper shows that conformationally changed fibrinogen can expose the sites A alpha-(148-160) and gamma-(312-324) involved in stimulation of the tissue-type plasminogen activator (t-PA)-catalysed plasminogen activation. The exposure of the stimulating sites was determined by ELISA using mABs directed

Questions

  1. Hi. I received fly-pro-arg-pro. G1895 5 mg. CAS-No:67869-629. You don’t mention where to dilute it and how much to dilute the powder in. Can you please help?

    1 answer
    1. This product is soluble in 0.05 M acetic acid (10 mg/ml) as well as water (1 mg/ml).

      Helpful?

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