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F133

Sigma-Aldrich

Norfluoxetine hydrochloride

≥97%, solid

Sinonimo/i:

(±)-γ-(4-Trifluoromethylphenoxy)benzenepropanamine hydrochloride

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About This Item

Formula empirica (notazione di Hill):
C16H16F3NO · HCl
Numero CAS:
57226-68-3
Peso molecolare:
331.76
Numero MDL:
MFCD01321043
Codice UNSPSC:
12352200
ID PubChem:
24894760
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥97%

Stato

solid

Colore

yellow

Solubilità

H2O: >4 mg/mL
DMSO: >5 mg/mL

Stringa SMILE

Cl[H].NCCC(Oc1ccc(cc1)C(F)(F)F)c2ccccc2

InChI

1S/C16H16F3NO.ClH/c17-16(18,19)13-6-8-14(9-7-13)21-15(10-11-20)12-4-2-1-3-5-12;/h1-9,15H,10-11,20H2;1H
GMTWWEPBGGXBTO-UHFFFAOYSA-N

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Applicazioni

Norfluoxetine hydrochloride has been used to examine if psychoactive pharmaceuticals in drinking water at environmental concentrations could induce neuronal gene expression. It has also been used to examine whether at environmental concentrations it can alter in vitro expression of autism spectrum disorders (ASD)-associated synaptic proteins in human neurons.

Azioni biochim/fisiol

Fluoxetine metabolite; more potent inhibitor of serotonin uptake than fluoxetine with a half-life in vivo of 5-7 days.
Norfluoxetine is an active metabolite of fluoxetine. It disturbs the production of estrogen in a co-culture model of the feto-placental unit.

Avvertenza

Hygroscopic, photosensitive

Note legali

Sold under license from Eli Lilly and Company.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
101M4621V
038K4611
086K2040
045K1821
035K1075

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Robert K McNamara et al.
Progress in neuro-psychopharmacology & biological psychiatry, 34(7), 1317-1321 (2010-07-27)
Omega-3 (n-3) polyunsaturated fatty acids (PUFA) and fluoxetine (FLX) have additive effects in the treatment of major depressive disorder, and FLX up-regulates genes that regulate fatty acid biosynthesis in vitro. Although these data suggest that FLX may augment n-3 fatty
M Koelch et al.
Pharmacopsychiatry, 45(2), 72-76 (2011-11-17)
Information about therapeutic serum levels of fluoxetine (FLX) and its major metabolite norfluoxetine (NORFLX) in children and adolescents is scarce. Therapeutic drug monitoring (TDM) of FLX was routinely performed in 71 subjects treated for a major depressive disorder (MDD) (10-60
W Abdel-Razaq et al.
Neurochemical research, 36(2), 327-338 (2010-12-02)
The in vitro effects of antidepressant drugs on mitochondrial function were investigated in a CHOβ(2)SPAP cell line used previously to determine the effects of antidepressants on gene transcription (Abdel-Razaq et al., Biochem Pharmacol 73:1995-2003, 2007) and in rat heart isolated
E K Sawyer et al.
Pharmacology, 88(1-2), 44-49 (2011-07-16)
Fluoxetine (Prozac) is a selective serotonin reuptake inhibitor currently used to treat depression and mood disorders. It has been widely studied clinically and preclinically, yet there is limited knowledge of its pharmacokinetics in nonhuman primates. The present study characterized the
Fluoxetine and its active metabolite norfluoxetine disrupt estrogen synthesis in a co-culture model of the feto-placental unit
Thibeault A A H, et al.
Molecular and cellular endocrinology, 442, 32-39 (2017)
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