E1032
Anti-EN-RAGE antibody produced in goat
affinity isolated antibody, lyophilized powder
Sinonimo/i:
Anti-CAGC, Anti-S100 calcium binding protein A12, Anti-S100A12, Anti-p6
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100 μG
CHF 614.00
CHF 614.00
Spedizione prevista il30 maggio 2025
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Cambia visualizzazione
100 μG
CHF 614.00
About This Item
Codice UNSPSC:
12352203
NACRES:
NA.43
CHF 614.00
Spedizione prevista il30 maggio 2025
Prodotti consigliati
Origine biologica
goat
Livello qualitativo
Coniugato
unconjugated
Forma dell’anticorpo
affinity isolated antibody
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Stato
lyophilized powder
Reattività contro le specie
human
tecniche
flow cytometry: suitable (0.25µg/106 cells)
immunohistochemistry: 5-15 μg/mL
western blot: 0.1-0.2 μg/mL
N° accesso UniProt
Temperatura di conservazione
−20°C
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... S100A12(6283)
Descrizione generale
EN-RAGE is a member of the S100/calgranulin superfamily.
Immunogeno
purified, E. coli-derived recombinant human extracellular RAGE-binding protein.
Applicazioni
Anti-EN-RAGE antibody produced in goat is suitable for western blot analysis at a working concentration of 0.1–0.2μg/mL, immunohistochemistry at 5-15μg/mL and flow cytometry at 3-10μg/mL/106 cells.
Azioni biochim/fisiol
The gene encodes a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response.[1] It stimulates innate immune cells via binding to receptor for advanced glycation end products (AGER), which activates the MAP-kinase and NF-κ-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. It also stimulates mast cell degranulation and activation which generates chemokines, histamine and cytokines with leukocyte recruitment to the sites of inflammation.
Stato fisico
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
13 - Non Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
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Zheng Yang et al.
The Journal of allergy and clinical immunology, 119(1), 106-114 (2007-01-09)
The calcium-binding protein S100A12 might provoke inflammation and monocyte recruitment through the receptor for advanced glycation end products. Because inflammation elicited by S100A12 in vivo had characteristics of mast cell (MC) activation, we aimed to define the mechanism. Various MC
Olga V Moroz et al.
BMC biochemistry, 10, 11-11 (2009-04-24)
Human S100A12 is a member of the S100 family of EF-hand calcium-modulated proteins that are associated with many diseases including cancer, chronic inflammation and neurological disorders. S100A12 is an important factor in host/parasite defenses and in the inflammatory response. Like
Wei Xing Yan et al.
The Journal of biological chemistry, 283(19), 13035-13043 (2008-02-23)
S100A12 is expressed at sites of acute, chronic, and allergic inflammation. S100 proteins have regions of high sequence homology, but the "hinge" region between the conserved calcium binding domains is structurally and functionally divergent. Because the murine S100A8 hinge domain
A M Cole et al.
FEBS letters, 504(1-2), 5-10 (2001-08-28)
The human airways are protected from pathogenic colonization by a blanket of fluid impregnated with innate antimicrobial effector molecules. Among several previously uncharacterized components, we isolated a peptide that had activity primarily targeting Gram-negative bacteria. We named the peptide 'calcitermin'
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