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C5913

Sigma-Aldrich

4-Chloromercuribenzoic acid

cysteine active site modifier

Sinonimo/i:

4-(Chloromercurio)benzoic acid, 4-(Hydroxymercuri)benzoic acid

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About This Item

Formula condensata:
ClHgC6H4CO2H
Numero CAS:
59-85-8
Peso molecolare:
357.16
Beilstein:
3662892
Numero CE:
200-442-6
Numero MDL:
MFCD00002526
Codice UNSPSC:
12352202
ID PubChem:
24278323
NACRES:
NA.77

Descrizione

cysteine active site modifier

Saggio

≥98.5% (HPLC)

Stato

powder

Punto di fusione

287 °C (dec.) (lit.)

Solubilità

1 M NaOH: 20 mg/mL, clear, colorless

Stringa SMILE

OC(=O)c1ccc([Hg]Cl)cc1

InChI

1S/C7H5O2.ClH.Hg/c8-7(9)6-4-2-1-3-5-6;;/h2-5H,(H,8,9);1H;/q;;+1/p-1
YFZOUMNUDGGHIW-UHFFFAOYSA-M

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Applicazioni

Can be used to inhibit some enzymes that require unmodified cysteine residues (e.g., adenylyl cyclase).

Esclusione di responsabilità

For U.S. Customers: Contains mercury; Do not place in trash - dispose according to local, state, or federal laws.

Avvertenze

Danger

Indicazioni di pericolo

H300 + H310 + H330,H373,H410

Classi di pericolo

Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2

Codice della classe di stoccaggio

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
STBJ8646
STBJ7475
076K1087
125K1080
097H0664

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Sigma-Aldrich

E6758

Ethylenediaminetetraacetic acid

Fenil metansolfonile fluoruro ≥98.5% (GC)

Sigma-Aldrich

P7626

Fenil metansolfonile fluoruro

Margaret Yole et al.
Toxicology, 231(1), 40-57 (2007-01-11)
The effects of 1 min-4 h exposures to four Hg compounds (mercuric chloride [HgCl2], methyl mercuric chloride [CH3HgCl], p-chloromercuribenzoate [p-CMB] and thimerosal [TMS; ethylmercurithiosalicylate]) on cell death, microtubules, actin, CD3 receptor expression, protein tyrosine phosphorylation (PTyr-P) and intracellular calcium ([Ca2+]i)
Mamoon Rashid et al.
The Journal of pharmacology and experimental therapeutics, 335(3), 754-761 (2010-09-24)
We have discovered a non-AT(1), non-AT(2) angiotensin binding site in rodent and human brain membranes, which, based on its pharmacological/biochemical properties and tissue distribution, is different from angiotensin receptors and key proteases processing angiotensins. In this study, the novel angiotensin
Suresh Katragadda et al.
International journal of pharmaceutics, 320(1-2), 104-113 (2006-05-25)
The aim of this study is to identify the class of enzymes responsible for the hydrolysis of amino acid and dipeptide prodrugs of acyclovir (ACV) and to modulate transport and metabolism of amino acid and dipeptide prodrugs of acyclovir by
Dmitriy Minond et al.
Bioorganic & medicinal chemistry, 17(14), 5027-5037 (2009-06-26)
VIM-2 is an Ambler class B metallo-beta-lactamase (MBL) capable of hydrolyzing a broad-spectrum of beta-lactam antibiotics. Although the discovery and development of MBL inhibitors continue to be an area of active research, an array of potent, small molecule inhibitors is
Friederike Stumpff et al.
Pflugers Archiv : European journal of physiology, 457(5), 1003-1022 (2008-08-22)
The absorption of short-chain fatty acids (SCFA) from the rumen requires efficient mechanisms for both apical uptake and basolateral extrusion. Previous studies suggest that the rumen expresses a basolateral chloride conductance that might be permeable to SCFA. In order to
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